PMID- 7422704 OWN - NLM STAT- MEDLINE DCOM- 19801218 LR - 20190712 IS - 0091-3057 (Print) IS - 0091-3057 (Linking) VI - 13 IP - 3 DP - 1980 Sep TI - Differential effects of methylphenidate on signalled and non-signalled reinforcement. PG - 467-70 AB - Rats were trained to press a bar with water reinforcement under a variable interval 15-sec (VI 15), variable interval 15-sec signalled-reinforcement (VI SD), or a differential-reinforcement-of-low-rate 10-sec (DRL 10) schedule. Methylphenidate (MP) had little effect on response rates or reinforcements-earned in the VI 15 group. However, MP increased response rates in a dose-related manner in the VI SD and the DRL 10 groups. These findings and additional results reported in the literature suggest that signalled reinforcement does not necessarily antagonize the rate-increasing effects of the amphetamine-type drugs. FAU - Emmett-Oglesby, M W AU - Emmett-Oglesby MW FAU - Taylor, K E AU - Taylor KE FAU - Dafter, R E AU - Dafter RE LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Pharmacol Biochem Behav JT - Pharmacology, biochemistry, and behavior JID - 0367050 RN - 207ZZ9QZ49 (Methylphenidate) SB - IM MH - Animals MH - Conditioning, Operant/*drug effects MH - Cues MH - Extinction, Psychological/drug effects MH - Male MH - Methylphenidate/*pharmacology MH - Rats MH - Reinforcement Schedule EDAT- 1980/09/01 00:00 MHDA- 1980/09/01 00:01 CRDT- 1980/09/01 00:00 PHST- 1980/09/01 00:00 [pubmed] PHST- 1980/09/01 00:01 [medline] PHST- 1980/09/01 00:00 [entrez] AID - 0091-3057(80)90257-9 [pii] AID - 10.1016/0091-3057(80)90257-9 [doi] PST - ppublish SO - Pharmacol Biochem Behav. 1980 Sep;13(3):467-70. doi: 10.1016/0091-3057(80)90257-9.