PMID- 7426354
OWN - NLM
STAT- MEDLINE
DCOM- 19810116
LR  - 20191023
IS  - 0007-0971 (Print)
IS  - 0007-0971 (Linking)
VI  - 74
IP  - 2
DP  - 1980 Apr
TI  - Response of the lung airway to exercise testing in asthma and rhinitis.
PG  - 155-63
AB  - The reactivity of the large and small airways of the lung in a group of ten 
      atopic subjects with rhinitis was compared with that in ten non-atopic control 
      subjects and in 17 with atopic asthma. Atopic state was assessed by skin prick 
      testing with 22 common allergens and by measurement of total serum immunoglobulin 
      E (IgE) antibody. The atopic state of the rhinitis and asthma patients was 
      similar. Exercise provocation tests were performed on each subject and changes in 
      airway function were measured by peak expiratory flow rate, forced expiratory 
      volume in one second, vital capacity, maximal expiratory flow volume curves and 
      closing volume. There were no statistically significant differences between the 
      changes in lung function after exercise in the rhinitis patients compared with 
      the controls. There were, however, statistically significant changes in all the 
      measurements of respiratory function in those with asthma compared with the other 
      two groups. The falls in forced expiratory flow rates in the asthmatic subjects 
      were greater at lower lung volumes than near the total lung capacity, perhaps 
      indicating that narrowing of small, as well as large, airways was occurring. No 
      correlation was found between the magnitude of the airway response to exercise 
      and either the total serum IgE antibody or the mean weal diameter of positive 
      skin tests in each subject. Atopic subjects with rhinitis but not asthma showed 
      no evidence of bronchial hyper-reactivity on exercise testing. It is therefore 
      suggested that single exercise provocation test can discriminate subjects with 
      atopic asthma from those with other atopic disorders.
FAU - Schofield, N M
AU  - Schofield NM
FAU - Green, M
AU  - Green M
FAU - Davies, R J
AU  - Davies RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Dis Chest
JT  - British journal of diseases of the chest
JID - 7511123
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/immunology/*physiopathology
MH  - Forced Expiratory Flow Rates
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Lung/*physiopathology
MH  - Male
MH  - *Physical Exertion
MH  - Respiratory Function Tests
MH  - Rhinitis, Allergic, Perennial/immunology/*physiopathology
MH  - Skin Tests
EDAT- 1980/04/01 00:00
MHDA- 1980/04/01 00:01
CRDT- 1980/04/01 00:00
PHST- 1980/04/01 00:00 [pubmed]
PHST- 1980/04/01 00:01 [medline]
PHST- 1980/04/01 00:00 [entrez]
AID - 10.1016/0007-0971(80)90027-3 [doi]
PST - ppublish
SO  - Br J Dis Chest. 1980 Apr;74(2):155-63. doi: 10.1016/0007-0971(80)90027-3.