PMID- 7435591
OWN - NLM
STAT- MEDLINE
DCOM- 19810126
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 239
IP  - 3
DP  - 1980 Sep
TI  - 5-Thio-D-glucose: hypothermic responses in mice.
PG  - R214-8
AB  - Adult male mice were administered several doses of 5-thio-D-glucose (5-TG) at two 
      environmental temperatures, 4 and 22 degrees C. Both intracerebroventricular 
      (icv) and intraperitoneal (ip) administration of 5-TG resulted in significant (P 
      < 0.05 to P < 0.001) decrements in rectal temperature (Tre) that were dose 
      dependent. After 30 min, the hypothermic effects were significantly (P < 0.001, 
      icv, 100 microgram) exacerbated by cold exposure (4 vs. 22 degrees C) and were 
      likewise intensified significantly (P < 0.005, 45 min, fed vs. 18 h fasted) by 
      food deprivation. These reductions in Tre were accompanied by significant (P < 
      0.001) increases in circulating levels of glucose. The present results indicate 
      that 5-TG may be eliciting both central and peripheral cellular glucopenia 
      concomitant with circulatory hyperglycemia; thus, the resultant hypothermia may 
      be arising from competitive inhibition of glycolysis by 5-TG intermediates as 
      well as reduced availability of tissue glucose.
FAU - Francesconi, R
AU  - Francesconi R
FAU - Mager, M
AU  - Mager M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 3PRV1384UO (5-thio-D-glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - *Body Temperature Regulation
MH  - Dose-Response Relationship, Drug
MH  - Glucose/*analogs & derivatives/metabolism/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
EDAT- 1980/09/01 00:00
MHDA- 1980/09/01 00:01
CRDT- 1980/09/01 00:00
PHST- 1980/09/01 00:00 [pubmed]
PHST- 1980/09/01 00:01 [medline]
PHST- 1980/09/01 00:00 [entrez]
AID - 10.1152/ajpregu.1980.239.3.R214 [doi]
PST - ppublish
SO  - Am J Physiol. 1980 Sep;239(3):R214-8. doi: 10.1152/ajpregu.1980.239.3.R214.