PMID- 7438579
OWN - NLM
STAT- MEDLINE
DCOM- 19810219
LR  - 20190512
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 3
IP  - 4
DP  - 1980 Aug
TI  - Role of aminophylline in refractory heart failure: a comparison to the 
      vasodilator sodium nitroprusside, the old and the new.
PG  - 268-75
AB  - Aminophylline [(theophylline ethylene diamine (TED)] reportedly improved cardiac 
      hemodynamics by lowering vascular resistances and increasing contractility. TED 
      as used clinically has not been compared to the vasodilator sodium nitroprusside 
      (NP). To assess the relative hemodynamic effects of these two commonly used 
      agents, the following comparison was made. Ten patients with congestive 
      cardiomyopathy in chronic refractory heart failure [New York Heart Association 
      (NYHA) class IV] were studied. All patients demonstrated cardiomegaly by chest x 
      ray and echocardiography (LVd = 6.3 +/- 0.7 cm) and markedly abnormal 
      hemodynamics during baseline observations (see Table I). Hemodynamic measurements 
      at baseline were compared after TED infusion (mean blood level = 16 +/- 12 
      micrograms/m/TED) and during intravenous NP. No significant changes in heart rate 
      occurred during either therapeutic intervention; a fall in mean arterial pressure 
      of 10 mmHg (p < 0.01) was observed during NP therapy; atrioventricular (AV) block 
      with ventricular fibrillation was successfully treated in one patient after TED. 
      Theophylline ethylene diamine demonstrated no detectable cardiac hemodynamic 
      effects 60--90 min post infusion despite proven blood levels, whereas NP 
      exhibited distinctly beneficial effects in this patient group. Previous studies 
      demonstrating improved hemodynamics occurring with TED have been limited to the 
      time of infusion or within the following 40 min, a time when TED blood levels are 
      maximum and therefore closest to toxicity. The results of this study suggest that 
      TED demonstrates no beneficial hemodynamic effects in refractory heart failure as 
      early as 1 h after infusion despite blood levels in the therapeutic range.
FAU - DiBianco, R
AU  - DiBianco R
FAU - Rosenfeld, S P
AU  - Rosenfeld SP
FAU - Katz, R J
AU  - Katz RJ
FAU - Simpson, A G
AU  - Simpson AG
FAU - Fletcher, R D
AU  - Fletcher RD
FAU - Singh, S
AU  - Singh S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Ferricyanides)
RN  - 169D1260KM (Nitroprusside)
RN  - 27Y3KJK423 (Aminophylline)
SB  - IM
MH  - Aged
MH  - Aminophylline/adverse effects/pharmacology/*therapeutic use
MH  - Ferricyanides/*therapeutic use
MH  - Heart Failure/blood/*drug therapy/physiopathology
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitroprusside/pharmacology/*therapeutic use
EDAT- 1980/08/01 00:00
MHDA- 1980/08/01 00:01
CRDT- 1980/08/01 00:00
PHST- 1980/08/01 00:00 [pubmed]
PHST- 1980/08/01 00:01 [medline]
PHST- 1980/08/01 00:00 [entrez]
AID - 10.1002/clc.4960030209 [doi]
PST - ppublish
SO  - Clin Cardiol. 1980 Aug;3(4):268-75. doi: 10.1002/clc.4960030209.