PMID- 7441319
OWN - NLM
STAT- MEDLINE
DCOM- 19810219
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 44
IP  - 5
DP  - 1980 Nov
TI  - Excitability of female rat central gray cells with medullary projections: changes 
      produced by hypothalamic stimulation and estrogen treatment.
PG  - 1012-23
AB  - 1. Effects of estrogen on the excitability of 74 neurons in the central gray of 
      the mesencephalon (CG) antidromically identified from the medulla were 
      investigated extracellularly in female rats under urethan anesthesia. 2. The mean 
      rate of spontaneous discharge of the identified CG cells was higher in 
      estrogen-treated (2.9 Hz) than in untreated ovariectomized rats (0.3 Hz). In the 
      estrogen-treated preparations, 18.5% of the identified cells had discharge rates 
      exceeding 3.0 Hz, while none were found in this range in the untreated animals. 
      3. Two types of positive-negative biphasic antidromic spike potentials were 
      distinguished. In one ("fast") the initial positive deflection was completed 
      within 500-700 microseconds, while it took longer than 1 ms in the other ("slow" 
      spikes). Slow spikes had a notch in the rising phase of their initial positive 
      deflection, at which antidromic propagation was often blocked. Mean antidromic 
      spike latency for the fast spikes was 6.8 ms, while the value for the slow spikes 
      was 14.7 ms. 4. In slow spikes, the percentage of successful antidromic spike 
      invasions into the somatodendritic complex remained constant for a long time when 
      the response was elicited by repetitive antidromic stimuli at 0.5 Hz. Antidromic 
      propagation into the somatodendritic complex occurred more frequently in the slow 
      spikes recorded from estrogen-treated preparations (94.2%) than in those of 
      ovariectomized untreated animals (55.7%). 5. Electrical stimulation of the 
      preoptic area (POA) reduced the frequency of successful antidromic propagation 
      into the somatodendritic complex. Stimulation of the ventromedial nucleus of the 
      hypothalamus (VMN) increased it. Conversely, electrolytic lesion of the POA 
      facilitated, while VMN lesion reduced antidromic spike invasion. 6. Thus, 
      excitability of some neurons in the CG is facilitated by estrogen. Similar 
      effects of VMN stimulation and POA lesion suggest that the estrogenic effect 
      could be mediated by these structures. The pattern of effects on these CG neurons 
      is that required for their control of lordosis behavior, an estrogen-dependent 
      postural reflex in female rodents. These cells may modulate medullary 
      reticulospinal cells, which in turn govern the reflex.
FAU - Sakuma, Y
AU  - Sakuma Y
FAU - Pfaff, D W
AU  - Pfaff DW
LA  - eng
GR  - HD-05751/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Estrogens)
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Estrogens/*pharmacology
MH  - Female
MH  - Hypothalamus/*physiology
MH  - Medulla Oblongata/drug effects/*physiology
MH  - Mesencephalon/drug effects/*physiology
MH  - Neural Pathways/physiology
MH  - Posture
MH  - Preoptic Area/physiology
MH  - Rats
MH  - Sexual Behavior, Animal/physiology
MH  - Stimulation, Chemical
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
AID - 10.1152/jn.1980.44.5.1012 [doi]
PST - ppublish
SO  - J Neurophysiol. 1980 Nov;44(5):1012-23. doi: 10.1152/jn.1980.44.5.1012.