PMID- 7461793
OWN - NLM
STAT- MEDLINE
DCOM- 19810424
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 2
IP  - 6
DP  - 1980 Nov-Dec
TI  - Renal sodium excretion and the peritubular capillary physical factors in 
      essential hypertension.
PG  - 771-9
AB  - Peritubular capillary hydrostatic and oncotic forces and their relationship to 
      the renal excretion of sodium (UNaV) were examined in 19 patients with moderate 
      and uncomplicated essential hypertension (HT) and compared with data from 20 
      normotensive subjects (NT). Observations were made in hydropenia (C) and during 
      sustained isotonic saline volume expansion (E; 3% increase in body weight). The 
      intrarenal venous pressure (IRVP) was used as an index of peritubular capillary 
      hydrostatic pressure, and the efferent arteriolar colloid osmotic pressure 
      (COPeff) was estimated from the arterial COP and the filtration fraction. C 
      values (mean +/- SEM) in HT (and NT) were: arterial pressure (MAP) 110 +/- 3 mm 
      Hg (85 +/- 1, p less than 0.001); glomerular filtration rate (GFR) 122 +/- 4 
      ml/min/1.73 m2 (128 +/- 3, p greater than 0.05); renal blood flow (RBF) 1172 +/- 
      38 ml/min/1.73 m2 (1298 +/- 48, p less than 0.05); IRVP 25.0 +/- 1.0 mm Hg (24.8 
      +/- 0.8, p greater than 0.05); COPeff 33.0 +/- 0.7 mm Hg (31.9 +/- 0.6, p greater 
      than 0.05); and UNaV 140 +/- 13 mumole/min (161 +/- 12, p greater than 0.05). 
      During E, the increase of UNaV in HT was more than double that of NT (p less than 
      0.001) while IRVP did not change in either group (p greater than 0.05); and 
      COPeff fell by 26% (p less than 0.001) in both groups. GFR and RBF increased by 
      18% (p less than 0.001) and 19% (p less than 0.001) respectively, in HT, but did 
      not change in NT. MAP remained unchanged in both groups. The results indicate 
      that the peritubular capillary physical factors are normal in established 
      essential hypertension, and that these forces are not involved in the exaggerated 
      natriuretic response to volume expansion in essential hypertension.
FAU - Willassen, Y
AU  - Willassen Y
FAU - Ofstad, J
AU  - Ofstad J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - *Capillary Permeability
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Hydrostatic Pressure
MH  - Hypertension/*physiopathology
MH  - Kidney Tubules/*blood supply
MH  - Male
MH  - Middle Aged
MH  - *Natriuresis
MH  - Osmotic Pressure
MH  - Regional Blood Flow
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
AID - 10.1161/01.hyp.2.6.771 [doi]
PST - ppublish
SO  - Hypertension. 1980 Nov-Dec;2(6):771-9. doi: 10.1161/01.hyp.2.6.771.