PMID- 7463349
OWN - NLM
STAT- MEDLINE
DCOM- 19810421
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 216
IP  - 2
DP  - 1981 Feb
TI  - Pharmacological studies on 5-methoxymethyl-2'-deoxyuridine: a new antiviral 
      agent.
PG  - 275-80
AB  - Pharmacokinetic and pharmacodynamic properties of 5-methoxymethyl-2'-deoxyuridine 
      (MMUdR), a drug with potent antiviral activity against herpes simplex virus, were 
      investigated. After i.v. administration of [2-14C]MMUdR at 50 and 25 mg/kg to 
      rats, the overall half life of the drug (T 1/2 Kel) was calculated to be 32 to 35 
      min. The biological half life of the drug (T 1/2 beta) was 89 min and the 
      distribution half life (T1/2 alpha) was 6 min. The specific volume of 
      distribution was calculated to be 1.28 to 1.35 liters/kg and the total body 
      clearance rate of the drug was 10 ml/min/kg. The data were analyzed on the basis 
      of a two-compartment open pharmacokinetic model. After i.p. administration of 50 
      mg/kg of [2-14C]MMUdR to mice, peak plasma levels of 35.6 micrograms/ml were 
      attained in 10 min. The highest tissue concentrations of [2-14C]MMUdR in mice 
      were 63 micrograms/g in kidneys (30 min) followed by 36 micrograms/g in liver and 
      spleen and 30 to 32 micrograms/g in lungs and gut (20 min). MMUdR did not undergo 
      biotransformation in plasma but urine was found to contain MMUdR (greater than 
      80%) and a small amount of radioactivity which comigrated with MMUdR 
      monophosphate. Administration of 500 mg/kg of MMUdR i.v. to New Zealand White 
      rabbits did not produce any observable effects on the heart rate, ECG pattern or 
      respiration rate. Vasodilation of 39-sec duration was observed immediately after 
      administration of MMUdR.
FAU - Meldrum, J B
AU  - Meldrum JB
FAU - Gupta, V S
AU  - Gupta VS
FAU - Taneja, A K
AU  - Taneja AK
FAU - Sisodia, C S
AU  - Sisodia CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Antiviral Agents)
RN  - 5116-22-3 (5-methoxymethyl-2'-deoxyuridine)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Animals
MH  - *Antiviral Agents/metabolism/pharmacology
MH  - Deoxyuridine/*analogs & derivatives/pharmacology
MH  - Erythrocytes/metabolism
MH  - Hemodynamics/drug effects
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Mice
MH  - Protein Binding
MH  - Respiration/drug effects
MH  - Tissue Distribution
EDAT- 1981/02/01 00:00
MHDA- 1981/02/01 00:01
CRDT- 1981/02/01 00:00
PHST- 1981/02/01 00:00 [pubmed]
PHST- 1981/02/01 00:01 [medline]
PHST- 1981/02/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1981 Feb;216(2):275-80.