PMID- 7466806
OWN - NLM
STAT- MEDLINE
DCOM- 19810421
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 131
IP  - 4
DP  - 1980 Aug
TI  - Human leukocyte antigen (HLA) in patients with idiopathic portal hypertension 
      (IPH).
PG  - 393-7
AB  - Both cryptogenic liver cirrhosis and idiopathic portal hypertension without 
      pathological findings of liver cirrhosis (IPH) are relatively common in Japan. To 
      find differrence between IPH and cryptogenic liver cirrhosis of Japanese, we 
      investigated human leukocyte antigen (HLA), familial clustering of liver diseases 
      as well as prevalence of HBs antigen in 31 patients with IPH. The age of patients 
      with IPH ranged between 6 and 67 years old (mean, 40 years). The ratio of female 
      to male in patients with IPH was 3.1. The incidence of chronic liver diseases in 
      the relatives of patients with cryptogenic liver cirrhosis was significantly high 
      (29.1%), whereas that in the relatives of patients with IPH was not high (12.9%) 
      as compared with hospitalized controls (8.9%). The phenotype frequencies of the 
      specificities of HLA A and B loci in patients with IPH did not differ from those 
      in healthy controls. And the incidence of HBs antigen and antibody in patient 
      with IPH (3.2% and 20.7%, respectively) was similar to those in normal subjects 
      in Japan. These findings suggest that IPH in Japan is a different clinical entity 
      from cryptogenic liver cirrhosis and that HB virus may not be one of the main 
      causes of IPH.
FAU - Satoh, H
AU  - Satoh H
FAU - Iwasaki, Y
AU  - Iwasaki Y
FAU - Ohkubo, A
AU  - Ohkubo A
FAU - Beppu, T
AU  - Beppu T
FAU - Futagawa, S
AU  - Futagawa S
FAU - Sugiura, M
AU  - Sugiura M
FAU - Juji, T
AU  - Juji T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Hypertension, Portal/*immunology
MH  - Liver Cirrhosis/genetics/immunology
MH  - Male
MH  - Middle Aged
EDAT- 1980/08/01 00:00
MHDA- 1980/08/01 00:01
CRDT- 1980/08/01 00:00
PHST- 1980/08/01 00:00 [pubmed]
PHST- 1980/08/01 00:01 [medline]
PHST- 1980/08/01 00:00 [entrez]
AID - 10.1620/tjem.131.393 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 1980 Aug;131(4):393-7. doi: 10.1620/tjem.131.393.