PMID- 7470684
OWN - NLM
STAT- MEDLINE
DCOM- 19810526
LR  - 20041117
IS  - 0395-3890 (Print)
IS  - 0395-3890 (Linking)
VI  - 17
IP  - 1
DP  - 1981 Jan-Feb
TI  - The effect of diffuse pulmonary fibrosis on lung mechanics.
PG  - 27-41
AB  - Maximum expiratory flow-volume curves (MEFV), inflational and deflational 
      pressure-volume curves, dynamic compliance at 20, 40, and 60 breaths per minute, 
      closing volume (single-breath oxygen method), standard lung volumes are airway 
      resistance measurements were made in eleven subjects with a clinical diagnosis of 
      diffuse interstitial fibrosis (DIF) and eleven control subjects. No subject was a 
      current cigarette smoker. Maximum flow-static recoil pressure curves (MFSR) were 
      constructed and calculations of upstream resistance (Rus) were made. Comparison 
      of the mean values showed no significant differences in airway resistance or 
      FEV1/FVC% between the two groups; however, significant differences were noted in 
      total lung capacity (TLC), forced expiratory volume in one second (FEV1) and 
      expiratory flow rates. Nine of the diseased subjects had pressure-volume curves 
      shifted to the right of the normal range, and a significant decrease in static 
      expired and inspired compliance was noted in the diseased group. Six subjects 
      with DIF showed increased Rus. The single-breath oxygen test results revealed an 
      increased slope of phase III (delta N2/I) in the diseased group. Decreases in the 
      static compliance may be explained by loss of lung volume in some patients with 
      DIF. There is also evidence that the small airways may be affected by this 
      disease process.
FAU - Murphy, D M
AU  - Murphy DM
FAU - Hall, D R
AU  - Hall DR
FAU - Petersen, M R
AU  - Petersen MR
FAU - Lapp, N L
AU  - Lapp NL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bull Eur Physiopathol Respir
JT  - Bulletin europeen de physiopathologie respiratoire
JID - 7605263
SB  - IM
MH  - Adult
MH  - Female
MH  - Forced Expiratory Flow Rates
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung Compliance
MH  - Male
MH  - Maximal Expiratory Flow-Volume Curves
MH  - Middle Aged
MH  - Pulmonary Diffusing Capacity
MH  - Pulmonary Fibrosis/*physiopathology
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
PST - ppublish
SO  - Bull Eur Physiopathol Respir. 1981 Jan-Feb;17(1):27-41.