PMID- 7471530
OWN - NLM
STAT- MEDLINE
DCOM- 19810521
LR  - 20061115
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 14
IP  - 6
DP  - 1980 Dec
TI  - Antibodies to DNA in patients undergoing long-term hemodialysis.
PG  - 288-93
AB  - It has been suggested that antibodies to native DNA occur with some frequency in 
      patients treated by hemodialysis. This has been attributed to the use of the 
      technique. We have investigated 48 patients on maintenance dialysis for the 
      presence of antibodies to single stranded DNA (ss-DNA) and native DNA (n-DNA) 
      compared to a control group of 25 nondialyzed patients with renal disease. In 
      neither group of patients were antibodies to ss-DNA detected frequently. 
      Antibodies to n-DNA were present in three of the dialyzed patients and in none of 
      the control group. The frequency of antibodies in dialysis patients was 
      insignificant in comparison to the same control group of non-dialyzed renal 
      patients. There was no correlation between duration of dialysis and development 
      of antibodies. A drug-induced lupus state is possible, but not established for 
      two of the three patients on dialysis.
FAU - Dasgupta, M K
AU  - Dasgupta MK
FAU - Davis, P
AU  - Davis P
FAU - Higgins, M R
AU  - Higgins MR
FAU - Dossetor, J B
AU  - Dossetor JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Antibodies)
RN  - 0 (DNA, Single-Stranded)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Antibodies/*immunology
MH  - DNA/*immunology
MH  - DNA, Single-Stranded/immunology
MH  - Female
MH  - Humans
MH  - Kidney Diseases/immunology
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 1980 Dec;14(6):288-93.