PMID- 7472958
OWN - NLM
STAT- MEDLINE
DCOM- 19951204
LR  - 20190710
IS  - 0022-3468 (Print)
IS  - 0022-3468 (Linking)
VI  - 30
IP  - 7
DP  - 1995 Jul
TI  - Effect of intraamniotic dexamethasone administration on intestinal absorption in 
      a rabbit gastroschisis model.
PG  - 983-6; discussion 986-7
AB  - Infants with gastroschisis experience delayed intestinal motility and absorption 
      for several weeks after birth. This intestinal dysfunction is believed to occur 
      primarily in the third trimester and to be largely caused by the prolonged 
      exposure of the intestine to amniotic fluid. Previous studies have shown that 
      prenatal steroid administration will enhance mucosal disaccharidase activity and 
      nutrient uptake. The present study evaluates the effects of dexamethasone on 
      intestinal function in a rabbit fetal gastroschisis model. Thirty-four fetuses 
      from 10 New Zealand white rabbits were divided into three groups: (1) 
      gastroschisis group (GSC, n = 10), gastroschisis was created on gestational day 
      (GD) 24 (term = 31 to 33 days); (2) dexamethasone group (GSD, n = 10), after the 
      creation of gastroschisis, a small osmotic pump was placed into the rabbit doe 
      for dexamethasone infusion into the fetal amniotic cavity for 7 days (0.2 
      microgram/g/d); (3) normal group (NF, n = 10), unoperated littermates from the 
      GSC group. There were no maternal deaths, and fetal survival rate was 85%. The 
      fetal small intestinal disaccharidase enzyme, lactase (UE/g protein), was 
      markedly decreased in GSC fetuses. It was increased 70% in the GSD group but 
      lower than in normal fetuses (GSC = 10.0 +/- 1.6; GSD = 17.3 +/- 1.6 [GSD versus 
      GSC, P < .05]; NF = 48.0 +/- 6.7). Maltase activity in the GSD group was 
      significantly increased (GSC = 7.2 +/- 1.1; GSD = 13.9 +/- 1.8 [GSD versus GSC, P 
      < .05]; NF = 12.2 +/- 1.3).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Guo, W
AU  - Guo W
AD  - Division of Pediatric Surgery, UCLA School of Medicine 90024, USA.
FAU - Swaniker, F
AU  - Swaniker F
FAU - Fonkalsrud, E W
AU  - Fonkalsrud EW
FAU - Vo, K
AU  - Vo K
FAU - Karamanoukian, R
AU  - Karamanoukian R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 3.2.1.- (Disaccharidases)
RN  - EC 3.2.1.108 (Lactase)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
RN  - EC 3.2.1.23 (beta-Galactosidase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Abdominal Muscles/*abnormalities/physiopathology
MH  - Amnion
MH  - Animals
MH  - Dexamethasone/administration & dosage/*therapeutic use
MH  - Disaccharidases/drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Diseases/*physiopathology
MH  - Gastrointestinal Motility/drug effects
MH  - Gestational Age
MH  - Glucose/metabolism
MH  - Hernia, Ventral/physiopathology
MH  - Infusion Pumps, Implantable
MH  - Injections
MH  - Intestinal Absorption/*drug effects
MH  - Intestinal Mucosa/drug effects/enzymology
MH  - Intestine, Small/*drug effects/enzymology
MH  - Lactase
MH  - Pregnancy
MH  - Rabbits
MH  - Survival Rate
MH  - alpha-Glucosidases/drug effects
MH  - beta-Galactosidase/drug effects
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 0022-3468(95)90326-7 [pii]
AID - 10.1016/0022-3468(95)90326-7 [doi]
PST - ppublish
SO  - J Pediatr Surg. 1995 Jul;30(7):983-6; discussion 986-7. doi: 
      10.1016/0022-3468(95)90326-7.