PMID- 7474560
OWN - NLM
STAT- MEDLINE
DCOM- 19951207
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 68
IP  - 3
DP  - 1995 Jul
TI  - Inhibitory effect of KBT-3022, a new anti-platelet agent, on infiltration of 
      polymorphonuclear leukocytes induced by leukotriene B4 or 
      formyl-methionyl-leucyl-phenylalanine in mice.
PG  - 353-7
AB  - We devised a method for evaluating polymorphonuclear leukocyte (PMN) infiltration 
      in vivo employing an air bleb technique combined with measurement of 
      myeloperoxidase (MPO) activity, and the effects of some anti-platelet agents were 
      evaluated. KBT-3022 (ethyl 
      2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate) and cilostazol 
      inhibited the increase in MPO activity in the connective tissue around the air 
      bleb induced by leukotriene B4 (LTB4) and formyl-methionyl-leucyl-phenylalanine 
      (fMLP). Indomethacin inhibited only the fMLP-induced increase in MPO activity, 
      but ticlopidine hydrochloride and acetylsalicylic acid had no effect. Histologic 
      observation confirmed the inhibition of PMN infiltration by KBT-3022. These 
      results indicate that KBT-3022 may be a potent inhibitor of both LTB4- and 
      fMLP-induced infiltration of PMNs.
FAU - Yokota, K
AU  - Yokota K
AD  - New Drug Research Laboratories, Kanebo, Ltd., Osaka, Japan.
FAU - Yamamoto, N
AU  - Yamamoto N
FAU - Obata, Y
AU  - Obata Y
FAU - Oda, M
AU  - Oda M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Pyrroles)
RN  - 0 (Thiazoles)
RN  - 101001-34-7 (KB 3022)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Dexamethasone/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Indomethacin/pharmacology
MH  - Leukocytes/*drug effects
MH  - Leukotriene B4/*pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - N-Formylmethionine Leucyl-Phenylalanine/*pharmacology
MH  - Platelet Aggregation Inhibitors/*pharmacology
MH  - Pyrroles/*pharmacology
MH  - Thiazoles/*pharmacology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1254/jjp.68.353 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1995 Jul;68(3):353-7. doi: 10.1254/jjp.68.353.