PMID- 7475977
OWN - NLM
STAT- MEDLINE
DCOM- 19951221
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 57
IP  - 24
DP  - 1995
TI  - Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation 
      without affecting cardiac functional capacity.
PG  - 2237-44
AB  - This study determined how selected functional, metabolic, and contractile 
      properties were impacted by sodium pivalate, a compound which creates a secondary 
      carnitine deficiency. Young male rats received either sodium pivalate (20 mM, 
      PIV) or sodium bicarbonate (20 mM, CONTR) in their drinking water. After 11-12 
      weeks cardiac function and glucose oxidation rates were measured in isolated, 
      perfused working heart preparations. Hearts were also analyzed for carnitine 
      content, activities of hexokinase (HK), citrate synthase (CS), and B-hydroxyacyl 
      CoA dehydrogenase (HOAD), and myosin isoenzyme distribution. Sodium pivalate 
      treatment significantly reduced cardiac carnitine content and increased glucose 
      oxidation but did not alter cardiac functional capacity. HK activity was 
      increased in the PIV group (p < 0.05), and HOAD activity decreased (p < 0.05). CS 
      activity and myosin isoform distribution (VI > 85%) remained unchanged. These 
      results demonstrate that pivalate treatment of this duration and the accompanying 
      carnitine deficiency shift cardiac substrate utilization without compromising 
      cardiac functional capacity.
FAU - Morris, G S
AU  - Morris GS
AD  - Department of Kinesiology, Louisiana State University, Baton Rouge 70803, USA.
FAU - Zhou, Q
AU  - Zhou Q
FAU - Wolf, B A
AU  - Wolf BA
FAU - Christos, S C
AU  - Christos SC
FAU - DiDomenico, D F
AU  - DiDomenico DF
FAU - Shug, A L
AU  - Shug AL
FAU - Paulson, D J
AU  - Paulson DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Isoenzymes)
RN  - 0 (Pentanoic Acids)
RN  - 813RE8BX41 (pivalic acid)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.6.4.1 (Myosins)
RN  - IY9XDZ35W2 (Glucose)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Animals
MH  - Carnitine/deficiency/*metabolism
MH  - Citrate (si)-Synthase/metabolism
MH  - Glucose/*metabolism
MH  - Heart/drug effects/*physiology
MH  - Hexokinase/metabolism
MH  - Isoenzymes/metabolism
MH  - Male
MH  - Myocardium/*metabolism
MH  - Myosins/metabolism
MH  - Oxidation-Reduction
MH  - Pentanoic Acids/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 0024320595022166 [pii]
AID - 10.1016/0024-3205(95)02216-6 [doi]
PST - ppublish
SO  - Life Sci. 1995;57(24):2237-44. doi: 10.1016/0024-3205(95)02216-6.