PMID- 7478449
OWN - NLM
STAT- MEDLINE
DCOM- 19951208
LR  - 20180216
IS  - 0301-1569 (Print)
IS  - 0301-1569 (Linking)
VI  - 57
IP  - 4
DP  - 1995 Jul-Aug
TI  - Expression of subtypes NF-L, NF-M and NF-H of neurofilament triplet proteins in 
      the developing rat inner ear.
PG  - 177-81
AB  - The expression of each subtype (NF-L, NF-M and NF-H) of neurofilament (NF) 
      triplet proteins in the developing rat inner ear was analysed using the 
      immunofluorescence method (FITC). On the 15th gestational day (GD), 
      immunostaining of NF subtypes did not occur in the otic region. On the 18th GD, 
      positivity for NF-L and NF-M occurred in nerve fibres in both the sensory and the 
      subepithelial layers of the inner ear but was lacking for NF-H. At 4 days after 
      birth immunoreactivity was present for each NF subtype but with topographic 
      differences in their distribution. The cell bodies of (different?) subpopulations 
      of vestibular and spiral ganglion cells were immunostained with monoclonal 
      antibodies for NF-L and NF-M, but a subpopulation of both vestibular and spiral 
      ganglion cells showed immunoreactivity for all three NF subtypes. The vestibular 
      nerve fibres and ganglion cells evidenced stronger positivity than cochlear nerve 
      fibres and spiral ganglion cells. This study confirms that the cytoskeletal 
      maturation of inner ear nerve fibres precedes the onset of at least the auditory 
      function by several days.
FAU - Nishizaki, K
AU  - Nishizaki K
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Uppsala University 
      Hospital, Sweden.
FAU - Anniko, M
AU  - Anniko M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (Intermediate Filament Proteins)
SB  - IM
MH  - Animals
MH  - Cochlear Nerve/cytology
MH  - Ear, Inner/*chemistry
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Intermediate Filament Proteins/*isolation & purification
MH  - Rats
MH  - Rats, Sprague-Dawley/*embryology
MH  - Spiral Ganglion/cytology
MH  - Vestibular Nerve/cytology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1159/000276735 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 1995 Jul-Aug;57(4):177-81. doi: 
      10.1159/000276735.