PMID- 748046
OWN - NLM
STAT- MEDLINE
DCOM- 19790611
LR  - 20141120
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 103
IP  - 6
DP  - 1978 Dec
TI  - The effects of dietary carbohydrate content on insulin binding and glucose 
      metabolism by isolated rat adipocytes.
PG  - 2252-63
AB  - The effects of changes in the amount of dietary carbohydrate (CHO) on cellular 
      insulin and glucose metabolism have been assessed in rat adipocytes. Feeding 
      animals a 67% CHO (fat-free) diet resulted in decreased insulin binding but 
      enhanced activity of both the glucose transport system and intracellular pathways 
      of glucose metabolism. Feeding rats a 67% fat (CHO-free) diet resulted in 
      decreased insulin receptors as well as decreased activity of the glucose 
      transport system and intracellular glucose metabolism. Therefore, the in vivo 
      insulin resistance caused by a high fat, low CHO diet seems to be adequately 
      explained, since all aspects of insulin's cellular action were depressed. On the 
      other hand, at first approximation, the increased in vivo insulin response caused 
      by a high CHO diet appears contradictory to the observed decrease in insulin 
      binding. However, a probable explanation for this apparent paradox is provided by 
      the enhanced activity of the cellular insulin effector systems distal to the 
      insulin receptor. Therefore, the increased in vivo insulin responsiveness after 
      high CHO feedings is most likely due to post receptor increases in various 
      aspects of glucose metabolism.
FAU - Olefsky, J M
AU  - Olefsky JM
FAU - Saekow, M
AU  - Saekow M
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Biological Transport, Active
MH  - Deoxyglucose/metabolism
MH  - *Dietary Carbohydrates
MH  - Dietary Fats
MH  - Glucose/*metabolism
MH  - In Vitro Techniques
MH  - Insulin/*metabolism
MH  - Kinetics
MH  - Male
MH  - Rats
MH  - Receptor, Insulin/*metabolism
EDAT- 1978/12/01 00:00
MHDA- 1978/12/01 00:01
CRDT- 1978/12/01 00:00
PHST- 1978/12/01 00:00 [pubmed]
PHST- 1978/12/01 00:01 [medline]
PHST- 1978/12/01 00:00 [entrez]
AID - 10.1210/endo-103-6-2252 [doi]
PST - ppublish
SO  - Endocrinology. 1978 Dec;103(6):2252-63. doi: 10.1210/endo-103-6-2252.