PMID- 7480771
OWN - NLM
STAT- MEDLINE
DCOM- 19951221
LR  - 20061115
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 197
IP  - 3
DP  - 1995 Dec
TI  - Decreased acute toxicity by using midline mucosa-sparing blocks during radiation 
      therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx.
PG  - 863-6
AB  - PURPOSE: To determine whether midline mucosa-sparing blocks (MSBs) protecting the 
      aerodigestive tract can statistically significantly reduce acute toxicity during 
      radiation therapy for carcinoma of the head and neck, without compromising tumor 
      control. MATERIALS AND METHODS: Radiation records and simulation films were 
      reviewed in 125 patients with carcinoma of the oral cavity, oropharynx, or 
      nasopharynx. Patients with and without MSBs were compared. Measures of acute 
      toxicity during radiation therapy were weight loss (> or = 5%), hospitalization 
      for nutritional support, and unplanned treatment interruptions (> or = 5 days). 
      Actuarial local-regional tumor control was compared. RESULTS: Patients with MSBs 
      had significantly less weight loss (26 of 50 vs 37 of 47 patients, P = .006), 
      fewer hospitalizations for nutritional support (one of 61 vs seven of 64 
      patients, P = .04), and a trend toward fewer treatment interruptions (10 of 61 vs 
      19 of 64 patients, P = .07) than patients without MSBs. The 3-year actuarial 
      tumor control rates in the neck were similar. CONCLUSION: Midline MSBs decrease 
      acute toxicity during radiation therapy for carcinoma of the oral cavity, 
      oropharynx, and nasopharynx without compromising tumor control.
FAU - Perch, S J
AU  - Perch SJ
AD  - Department of Radiation Oncology, University of Pennsylvania School of Medicine, 
      Philadelphia, USA.
FAU - Machtay, M
AU  - Machtay M
FAU - Markiewicz, D A
AU  - Markiewicz DA
FAU - Kligerman, M M
AU  - Kligerman MM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Actuarial Analysis
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma/*radiotherapy
MH  - Disease-Free Survival
MH  - Follow-Up Studies
MH  - Hospitalization
MH  - Humans
MH  - Middle Aged
MH  - Mouth Mucosa/*radiation effects
MH  - Mouth Neoplasms/*radiotherapy
MH  - Mucous Membrane/radiation effects
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Nasopharynx/*radiation effects
MH  - Nutritional Support
MH  - Oropharyngeal Neoplasms/*radiotherapy
MH  - Oropharynx/*radiation effects
MH  - Patient Care Planning
MH  - Radiation Protection/*instrumentation
MH  - Radiotherapy/adverse effects
MH  - Radiotherapy Dosage
MH  - Retrospective Studies
MH  - Stomatitis/etiology
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1148/radiology.197.3.7480771 [doi]
PST - ppublish
SO  - Radiology. 1995 Dec;197(3):863-6. doi: 10.1148/radiology.197.3.7480771.