PMID- 7485068
OWN - NLM
STAT- MEDLINE
DCOM- 19951207
LR  - 20190512
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 142
IP  - 11
DP  - 1995 Dec 1
TI  - Risk factors and cofactors for human T-cell lymphotropic virus type I 
      (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica.
PG  - 1212-20
AB  - Human T-cell lymphotropic virus type I (HTLV-I) has been etiologically associated 
      with a neurologic syndrome called HTLV-I-associated myelopathy/tropical spastic 
      paraparesis (HAM/TSP) as well as with adult T-cell leukemia/lymphoma. The authors 
      sought to quantify the risk in Jamaica of HAM/TSP associated with HTLV-I 
      infection and cofactors associated with this disease among infected individuals. 
      Between 1988 and 1989, prevalent and incident HAM/TSP patients and controls with 
      other neurologic diseases were enrolled in a retrospective study. A second 
      control group was composed of HTLV-I-seropositive, asymptomatic carriers in 
      Jamaica, ascertained in a separate study conducted in 1988. Although HTLV-I 
      seropositivity was not a component of the case definition for HAM/TSP, all 43 
      HAM/TSP patients were HTLV-I seropositive compared with two (4.0%) of the 
      controls with other neurologic diseases. Given HTLV-I seropositivity, one 
      cofactor associated with the risk of HAM/TSP was young age at initial 
      heterosexual confidence interval 1.29-12.46 for individuals aged < or = 15; odds 
      ratio = 4.26, 95% confidence interval 1.41-12.90 for individuals aged 16-17 years 
      at initial intercourse). Among individuals who reported this early age at initial 
      sexual intercourse, an increased risk of HAM/TSP was associated with having 
      reported more than five lifetime sexual partners (odds ratio = 2.88, 95% 
      confidence interval 0.90-8.70). Neither an early age at initial sexual 
      intercourse or the number of lifetime sexual partners was a risk factor for adult 
      T-cell leukemia/lymphoma. These data support the hypothesis that HAM/TSP is 
      associated with sexually acquired HTLV-I infection, whereas adult T-cell 
      leukemia/lymphoma is not.
FAU - Kramer, A
AU  - Kramer A
AD  - Viral Epidemiology Branch, National Cancer Institute, National Institutes of 
      Health, Rockville, MD, USA.
FAU - Maloney, E M
AU  - Maloney EM
FAU - Morgan, O S
AU  - Morgan OS
FAU - Rodgers-Johnson, P
AU  - Rodgers-Johnson P
FAU - Manns, A
AU  - Manns A
FAU - Murphy, E L
AU  - Murphy EL
FAU - Larsen, S
AU  - Larsen S
FAU - Cranston, B
AU  - Cranston B
FAU - Murphy, J
AU  - Murphy J
FAU - Benichou, J
AU  - Benichou J
AU  - et al.
LA  - eng
GR  - N01-CP-31006/CP/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Female
MH  - Humans
MH  - Jamaica/epidemiology
MH  - Leukemia-Lymphoma, Adult T-Cell/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/*epidemiology/immunology/transmission
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serologic Tests
MH  - Sexual Behavior
MH  - Sexually Transmitted Diseases, Viral/*epidemiology/immunology
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.aje.a117580 [doi]
PST - ppublish
SO  - Am J Epidemiol. 1995 Dec 1;142(11):1212-20. doi: 
      10.1093/oxfordjournals.aje.a117580.