PMID- 7485109
OWN - NLM
STAT- MEDLINE
DCOM- 19951228
LR  - 20190821
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 50
IP  - 4
DP  - 1995 Dec
TI  - Improved survival of patients with chronic myelogenous leukemia undergoing 
      allogeneic bone marrow transplantation.
PG  - 304-6
AB  - A total of 28 patients with chronic myelogenous leukemia (CML) in chronic phase 
      (CP) received bone marrow allografts from HLA-matched siblings at the University 
      of Florida between August 1984-July 1992. The present study compares the 
      disease-free survival (DFS) for those patients who were transplanted before or 
      after August 1988 using the same conditioning regimen. The analysis shows 
      significant difference in 3-year DFS for those patients transplanted post- vs. 
      pre-August 1988 (69.6% vs. 20%, respectively; P = 0.006). A decrease in 
      pneumonitis due to different etiologies from pre-August 1988 (6/13, 46%) to 
      post-August 1988 (1/15, 7%) was statistically significant (P = 0.029). A 
      decrease, although statistically insignificant, in the overall incidence and 
      severity of acute and chronic graft vs. host disease (GVHD) after August 1988 was 
      also noticed. This study indicates significantly improved outcome for patients 
      with CML in CP who have been treated in the University of Florida after August 
      1988. Better supportive care and prophylaxis for GVHD most likely contributed to 
      such improvement.
FAU - Moreb, J
AU  - Moreb J
AD  - Division of Medical Oncology, College of Medicine, University of Florida, 
      Gainesville 32610-0277, USA.
FAU - Johnson, T
AU  - Johnson T
FAU - Kubilis, P
AU  - Kubilis P
FAU - Myers, L
AU  - Myers L
FAU - Oblon, D
AU  - Oblon D
FAU - Miller, A
AU  - Miller A
FAU - Elfenbein, G
AU  - Elfenbein G
FAU - Weiner, R
AU  - Weiner R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Graft vs Host Disease/epidemiology
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*mortality/*therapy
MH  - Lung Diseases/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Time Factors
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1002/ajh.2830500416 [doi]
PST - ppublish
SO  - Am J Hematol. 1995 Dec;50(4):304-6. doi: 10.1002/ajh.2830500416.