PMID- 7485838
OWN - NLM
STAT- MEDLINE
DCOM- 19951218
LR  - 20190825
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 19
IP  - 4
DP  - 1995 Aug
TI  - Regional differences in the effects of chronic ethanol administration on 
      [3H]zolpidem binding in rat brain.
PG  - 910-4
AB  - A strong association has been observed between [3H]zolpidem binding and the 
      presence of gamma-aminobutyric acid (GABAA) receptor mRNA for alpha 1-, beta 2-, 
      and gamma 2-subunits in specific brain regions. This correlates with observed 
      sensitivity of individual neurons to zolpidem and ethanol in these same regions. 
      Previous studies using homogenate binding approaches showed small alterations in 
      [3H]zolpidem binding levels after chronic ethanol exposure. This study was 
      undertaken to ascertain if there is regional specificity of the effects of 
      chronic ethanol administration on [3H]zolpidem binding levels. Chronic ethanol 
      administration induced small, but significant alterations in [3H]zolpidem (5 nM) 
      binding in the inferior colliculus, substantia nigra, and the medial septum. 
      [3H]Zolpidem binding was increased in the inferior colliculus and substantia 
      nigra, and decreased in the medial septum. No significant differences in 
      [3H]zolpidem binding were noted in any other brain area analyzed, including the 
      cortex and cerebellum. These findings show that chronic ethanol administration 
      has small effects on [3H]zolpidem binding, although they occur in a site-specific 
      and bidirectional manner. Moreover, there is no correlation between changes in 
      [3H]zolpidem binding and alterations in GABAA receptor subunit expression.
FAU - Devaud, L L
AU  - Devaud LL
AD  - Department of Psychiatry, School of Medicine, University of North Carolina at 
      Chapel Hill 27599-7178, USA.
FAU - Morrow, A L
AU  - Morrow AL
FAU - Criswell, H E
AU  - Criswell HE
FAU - Breese, G R
AU  - Breese GR
FAU - Duncan, G E
AU  - Duncan GE
LA  - eng
GR  - AA-09013/AA/NIAAA NIH HHS/United States
GR  - AA-09122/AA/NIAAA NIH HHS/United States
GR  - ES07126/ES/NIEHS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, GABA-A)
RN  - 7K383OQI23 (Zolpidem)
SB  - IM
MH  - Alcoholism/*pathology
MH  - Animals
MH  - Autoradiography
MH  - Brain/*drug effects
MH  - Brain Mapping
MH  - Hypnotics and Sedatives/*pharmacokinetics
MH  - Male
MH  - Pyridines/*pharmacokinetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, GABA-A/*drug effects/metabolism
MH  - Zolpidem
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1111/j.1530-0277.1995.tb00966.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 1995 Aug;19(4):910-4. doi: 
      10.1111/j.1530-0277.1995.tb00966.x.