PMID- 7489755
OWN - NLM
STAT- MEDLINE
DCOM- 19960104
LR  - 20111117
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 25
IP  - 11
DP  - 1995 Nov
TI  - The presence of the HLA class II allele DPB1*0501 in ethnic Thais correlates with 
      an enhanced vaccine-induced antibody response to a malaria sporozoite antigen.
PG  - 3142-7
AB  - In this study, we examined the correlation between the frequency of allelic 
      variants of the class II human leukocyte antigen (HLA) DR, DQ and DP gene loci 
      and the quantitative humoral immune response observed in 71 Thai volunteers, 
      subsequent to vaccination with a conjugated subunit vaccine. This vaccine was 
      designed to induce antibodies directed against the immunodominant repeat region 
      of the Plasmodium falciparum circumsporozoite (CS) protein. The presence of the 
      DPB1*0501, a relatively common allele in Asian populations, was found to be 
      associated with high vaccine-induced CS repeat-specific antibody responses in the 
      volunteers. Given the increasing focus on the use of subunit vaccines in the 
      control of infectious diseases, consideration of the influence of class II allele 
      frequencies in ethnically diverse recipient populations may be important.
FAU - Stephens, H A
AU  - Stephens HA
AD  - Department of Transfusion Medicine, Siriraj Hospital and Medical School, Mahidol 
      University, Bangkok, Thailand.
FAU - Brown, A E
AU  - Brown AE
FAU - Chandanayingyong, D
AU  - Chandanayingyong D
FAU - Webster, H K
AU  - Webster HK
FAU - Sirikong, M
AU  - Sirikong M
FAU - Longta, P
AU  - Longta P
FAU - Vangseratthana, R
AU  - Vangseratthana R
FAU - Gordon, D M
AU  - Gordon DM
FAU - Lekmak, S
AU  - Lekmak S
FAU - Rungruang, E
AU  - Rungruang E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Malaria Vaccines)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibodies, Protozoan/*biosynthesis
MH  - Base Sequence
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - Humans
MH  - Immunization
MH  - Malaria Vaccines/administration & dosage/*immunology
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Thailand
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1002/eji.1830251123 [doi]
PST - ppublish
SO  - Eur J Immunol. 1995 Nov;25(11):3142-7. doi: 10.1002/eji.1830251123.