PMID- 7490916
OWN - NLM
STAT- MEDLINE
DCOM- 19960104
LR  - 20190516
IS  - 0025-6196 (Print)
IS  - 0025-6196 (Linking)
VI  - 70
IP  - 12
DP  - 1995 Dec
TI  - HLA-DQ associations in type 1 autoimmune hepatitis.
PG  - 1154-60
AB  - OBJECTIVE: To determine whether, in patients with type 1 autoimmune hepatitis and 
      human leukocyte antigen (HLA) DR3 and DR4 positivity, any DQ antigen is 
      disease-specific. MATERIAL AND METHODS: HLA class II typing was performed by 
      restriction fragment length polymorphism in 103 patients with type 1 autoimmune 
      hepatitis, 104 patients with chronic viral hepatitis, and 80 normal subjects. A 
      shared association with a disease-specific DQ antigen was sought in patients with 
      HLA-DR3, DR4, and DR3-DR4. RESULTS: Patients with HLA-DR3 and DR4 shared 
      positivity for DQ2, DQ4, DQ5, DQ6, and DQ7, but the associations reflected 
      established linkages or were of low frequency. Patients heterozygous for DR3-DR4 
      or homozygous for either DR3 or DR4 did not have a shared DQ antigen. Only the 
      DR3-DQ2 haplotype distinguished patients with autoimmune hepatitis from normal 
      subjects or those with chronic viral hepatitis. CONCLUSION: The DR3 and DR4 
      antigens are not associated with a single disease-specific DQ antigen in type 1 
      autoimmune hepatitis. The DR3-DQ2 haplotype is the principal risk factor for the 
      disease at our referral center. Analyses by restriction fragment length 
      polymorphism do not implicate a single susceptibility gene at the DQ locus.
FAU - Czaja, A J
AU  - Czaja AJ
AD  - Division of Gastroenterology and Internal Medicine, Mayo Clinic Rochester, MN 
      55905, USA.
FAU - Santrach, P J
AU  - Santrach PJ
FAU - Moore, S B
AU  - Moore SB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Autoimmune Diseases/genetics/*immunology
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR3 Antigen/*genetics
MH  - HLA-DR4 Antigen/*genetics
MH  - Haplotypes
MH  - Hepatitis/genetics/*immunology
MH  - Hepatitis, Viral, Human/genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Restriction Fragment Length
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - S0025-6196(11)63441-1 [pii]
AID - 10.4065/70.12.1154 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 1995 Dec;70(12):1154-60. doi: 10.4065/70.12.1154.