PMID- 7491294
OWN - NLM
STAT- MEDLINE
DCOM- 19960104
LR  - 20071114
IS  - 0163-5581 (Print)
IS  - 0163-5581 (Linking)
VI  - 24
IP  - 1
DP  - 1995
TI  - Dietary fat: gene expression and mammary tumorigenesis.
PG  - 13-21
AB  - Although discovered as an exogenous agent of mammary carcinoma, the mouse mammary 
      tumor virus (MMTV) is also transmitted vertically as endogenous proviral DNA 
      present in the germ line of all inbred mice. In the C3Hf mouse, which receives no 
      exogenous virus, the initial event of mammary tumorigenesis is the transcription 
      of the endogenous MMTV proviral DNA present at the Mtv-1 locus. Transcription 
      occurs as a result of the hormonal effects of pregnancy, and Mtv-1 specific 
      transcripts are seen in second-parity lactating mammary glands of these mice. As 
      a means of studying the effects of diet on mammary carcinoma at the 
      molecular/genetic level, we have studied the transcription of the Mtv-1 locus in 
      C3Hf mice on a high-fat diet containing 46% fat in calories or a low-fat diet 
      containing 10% fat in calories. We have detected an accelerated transcription of 
      the Mtv-1 locus (first- vs. second-parity lactating mammary glands) in > 50% of 
      the C3Hf mice on the high-fat diet. In addition, mice on the high-fat diet 
      developed mammary tumors earlier (11 vs. 17.8 mos) and after fewer litters (2.1 
      vs. 4.2). Our results indicate that fat in the diet can affect gene expression 
      related to mammary carcinoma.
FAU - Etkind, P R
AU  - Etkind PR
AD  - Department of Oncology, Montefiore Medical Center, Bronx, NY, USA.
FAU - Qiu, L
AU  - Qiu L
FAU - Lumb, K
AU  - Lumb K
LA  - eng
GR  - 13330/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 0 (DNA, Viral)
RN  - 0 (Dietary Fats)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - DNA, Viral/analysis/genetics/metabolism
MH  - Dietary Fats/*pharmacology
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/*drug effects
MH  - Mammary Glands, Animal/metabolism
MH  - Mammary Neoplasms, Experimental/*etiology/*genetics/metabolism
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Proviruses/genetics
MH  - RNA, Messenger/analysis/chemistry/genetics
MH  - RNA, Viral/analysis/genetics/metabolism
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1080/01635589509514389 [doi]
PST - ppublish
SO  - Nutr Cancer. 1995;24(1):13-21. doi: 10.1080/01635589509514389.