PMID- 7491936
OWN - NLM
STAT- MEDLINE
DCOM- 19960104
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 269
IP  - 5 Pt 1
DP  - 1995 Nov
TI  - Interleukin-1 beta-induced anorexia and pyrexia in rat: relationship to 
      hypothalamic neuropeptide Y.
PG  - E852-7
AB  - We investigated the effect of recombinant human interleukin-1 beta (rhIL-1 
      beta)-induced anorexia and pyrexia on the hypothalamic neuropeptide Y (NPY)-ergic 
      system, which stimulates feeding and reduces thermogenesis. In meal-fed rats, 
      food intake decreased by 83%, 90 min after IL-1 beta treatment (1.3 
      micrograms/100 g ip; n - 8) vs. controls. NPY concentrations were significantly 
      higher in the medial preoptic area (MPO), paraventricular (PVN), ventromedial 
      (VMN), and dorsomedial (DMN) nuclei but unchanged in the arcuate nucleus (ARC) in 
      both IL-1 beta-treated and pair-fed groups. Indomethacin (0.25 mg/100 g ip) 
      reduced IL-1 beta-induced anorexia and tended to normalize NPY concentrations. In 
      study 2, IL-1 beta increased core temperature by 1.1 degrees C above preinjection 
      values (P < 0.001) and significantly raised NPY concentrations in the MPO, PVN, 
      VMN, and DMN compared with controls, 60 min postinjection. Indomethacin prevented 
      the pyrexia and normalized hypothalamic NPY levels. As NPY concentrations were 
      not increased in the ARC (the hypothalamic site of synthesis), we suggest that 
      the increased NPY levels may result from blocked release, which would be in 
      accord with the known experimental effects of NPY.
FAU - McCarthy, H D
AU  - McCarthy HD
AD  - Department of Medicine, University of Liverpool, United Kingdom.
FAU - Dryden, S
AU  - Dryden S
FAU - Williams, G
AU  - Williams G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Interleukin-1)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Anorexia/*chemically induced/metabolism
MH  - Body Temperature/drug effects
MH  - Eating/drug effects
MH  - Fever/*chemically induced/metabolism
MH  - Humans
MH  - Hypothalamus/*metabolism
MH  - Interleukin-1/*pharmacology
MH  - Male
MH  - Neuropeptide Y/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Recombinant Proteins/pharmacology
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1152/ajpendo.1995.269.5.E852 [doi]
PST - ppublish
SO  - Am J Physiol. 1995 Nov;269(5 Pt 1):E852-7. doi: 10.1152/ajpendo.1995.269.5.E852.