PMID- 7492786
OWN - NLM
STAT- MEDLINE
DCOM- 19960111
LR  - 20231213
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 86
IP  - 11
DP  - 1995 Dec 1
TI  - High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
PG  - 4263-9
AB  - The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that 
      have previously been shown to be independently involved in myeloid malignant 
      proliferations. A search for rearrangement of the TEL locus in the region known 
      to be involved in t(12;21) was performed by Southern blotting in a panel of 
      hematopoietic malignancies. The presence of a t(12;21) was confirmed by 
      fluorescence in situ hybridization (FISH) and/or reverse transcriptase 
      (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is 
      specifically observed in at least 16% of the childhood B-lineage acute 
      lymphoblastic leukemia (ALL) investigated, none of which had been previously 
      identified as harboring t(12;21).
FAU - Romana, S P
AU  - Romana SP
AD  - U301 de l'Institut National de la Sante et de la Recherche Medicale, Paris, 
      France.
FAU - Poirel, H
AU  - Poirel H
FAU - Leconiat, M
AU  - Leconiat M
FAU - Flexor, M A
AU  - Flexor MA
FAU - Mauchauffe, M
AU  - Mauchauffe M
FAU - Jonveaux, P
AU  - Jonveaux P
FAU - Macintyre, E A
AU  - Macintyre EA
FAU - Berger, R
AU  - Berger R
FAU - Bernard, O A
AU  - Bernard OA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Burkitt Lymphoma/*genetics
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 12/genetics
MH  - *Chromosomes, Human, Pair 21/genetics
MH  - Cloning, Molecular
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/genetics
MH  - Polymerase Chain Reaction
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-ets
MH  - *Repressor Proteins
MH  - Transcription Factors/genetics
MH  - *Translocation, Genetic
MH  - ETS Translocation Variant 6 Protein
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - S0006-4971(20)63486-3 [pii]
PST - ppublish
SO  - Blood. 1995 Dec 1;86(11):4263-9.