PMID- 7493075
OWN - NLM
STAT- MEDLINE
DCOM- 19960111
LR  - 20190913
IS  - 1572-6495 (Print)
IS  - 1572-6495 (Linking)
VI  - 670
IP  - 1
DP  - 1995 Aug 4
TI  - Simultaneous determination of amphetamine, methamphetamine, 
      3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair 
      by gas chromatography-mass spectrometry.
PG  - 162-6
AB  - A procedure is presented for the simultaneous identification and quantification 
      of amphetamine (AP), methamphetamine (MA), methylenedioxyamphetamine (MDA) and 
      methylenedioxymethamphetamine (MDMA) in human hair. The method involves 
      decontamination of hair with dichloromethane and warm water, heat-alkaline 
      hydrolysis in the presence of deuterated internal standards, liquid-liquid 
      extraction and gas chromatography-mass spectrometry after derivatization with 
      pentafluoropropionic anhydride-pentafluoropropanol. The limit of detection for 
      AP, MA and MDA was 0.05 ng/mg using a 50-mg hair sample; for MDMA it was 0.1 
      ng/mg. Coefficients of variation ranged from 7 to 18%. This assay has been 
      successfully utilized in the evaluation of the deposition of the drugs in hair 
      obtained from various parts of the anatomy of a stimulant abuser.
FAU - Kintz, P
AU  - Kintz P
AD  - Institut de Medecine Legale, Strasbourg, France.
FAU - Cirimele, V
AU  - Cirimele V
FAU - Tracqui, A
AU  - Tracqui A
FAU - Mangin, P
AU  - Mangin P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chromatogr B Biomed Appl
JT  - Journal of chromatography. B, Biomedical applications
JID - 9421796
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analysis
MH  - Amphetamine/*analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - Methamphetamine/*analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Reproducibility of Results
MH  - Substance-Related Disorders/diagnosis
EDAT- 1995/08/04 00:00
MHDA- 1995/08/04 00:01
CRDT- 1995/08/04 00:00
PHST- 1995/08/04 00:00 [pubmed]
PHST- 1995/08/04 00:01 [medline]
PHST- 1995/08/04 00:00 [entrez]
AID - 037843479500160K [pii]
AID - 10.1016/0378-4347(95)00160-k [doi]
PST - ppublish
SO  - J Chromatogr B Biomed Appl. 1995 Aug 4;670(1):162-6. doi: 
      10.1016/0378-4347(95)00160-k.