PMID- 7494376
OWN - NLM
STAT- MEDLINE
DCOM- 19960111
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 68
IP  - 1
DP  - 1995 May
TI  - Loxiglumide, L-364,718 and L-365,260 prevent the inhibition of spontaneous 
      acetylcholine release from the frontal cerebral cortex of freely moving rat 
      peripherally administered with cholecystokinin-8S.
PG  - 129-32
AB  - We examined the effect of peripheral administration of cholecystokinin (CCK)-8S 
      on spontaneous acetylcholine (ACh) release from the frontal cortex and its 
      prevention by loxiglumide, L-364,718 and L-365,260 in freely moving rats using 
      intracerebral microdialysis. Subcutaneously (s.c.) administered CCK-8S at 10 and 
      30 micrograms/kg significantly decreased the release of ACh. The inhibitory 
      effect of 10 micrograms/kg (s.c.) CCK-8S was prevented by loxiglumide, a mixed 
      type of CCK-A and -B-receptor antagonist, at 1 mg/kg (intraperitoneal) and 40 
      micrograms/rat (intracerebroventricular, i.c.v.); L-364,718, a CCK-A-receptor 
      antagonist, at 125 and 250 ng/rat (i.c.v.); and L-365,260, a CCK-B-receptor 
      antagonist at 250 ng/rat (i.c.v.). These results demonstrate that peripherally 
      administered CCK-8S inhibits spontaneous ACh release from the frontal cortex 
      through both central CCK-A (mainly) and -B receptors.
FAU - Kimura, I
AU  - Kimura I
AD  - Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama 
      Medical and Pharmaceutical University, Japan.
FAU - Wakasono, S
AU  - Wakasono S
FAU - Kimura, M
AU  - Kimura M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Benzodiazepinones)
RN  - 0 (Phenylurea Compounds)
RN  - 0 (Receptors, Cholecystokinin)
RN  - 370JHF4586 (L 365260)
RN  - 77MPX3N42I (loxiglumide)
RN  - 9011-97-6 (Cholecystokinin)
RN  - EPL8W5565D (Proglumide)
RN  - JE6P7QY7NH (Devazepide)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*metabolism
MH  - Animals
MH  - Benzodiazepinones/*pharmacology
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Cholecystokinin/antagonists & inhibitors/*pharmacology
MH  - Devazepide
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Male
MH  - *Phenylurea Compounds
MH  - Proglumide/*analogs & derivatives/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Cholecystokinin/metabolism
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1254/jjp.68.129 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1995 May;68(1):129-32. doi: 10.1254/jjp.68.129.