PMID- 7496921
OWN - NLM
STAT- MEDLINE
DCOM- 19960116
LR  - 20210526
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 1
IP  - 1
DP  - 1994 Jan
TI  - Immunologic cross-reactivity between structural proteins of human T-cell 
      lymphotropic virus type I and the blood stage of Plasmodium falciparum.
PG  - 5-10
AB  - To determine the serologic cross-reactivity between human T-cell lymphotropic 
      virus type I (HTLV-I) and parasite antigens, we measured antibody responses 
      against HTLV-I, Plasmodium falciparum, Plasmodium vivax, and Brugia malayi in 
      serum specimens obtained from regions where malaria (n = 482) and filariasis (n = 
      101) are endemic. Analysis of immune reactivity to HTLV-I antigens showed that 
      specimens from regions where malaria is endemic had significantly higher rates of 
      enzyme immunoassay (EIA) reactivity (76 of 482 [15.8%] than those from regions 
      where filariasis is endemic (0 of 101 [0%]). Western blot (immunoblot) analysis 
      of the HTLV-I EIA-reactive specimens demonstrated predominant Gag reactivity 
      (HTLV-Iind). Only two specimens each from Indonesia and Brazil and four specimens 
      from Papua New Guinea had Env reactivity by radioimmunoprecipitation analysis. 
      Furthermore, a positive correlation between HTLV-EIA and titers of antibody to 
      the blood stage of P. falciparum (rs = 0.24, P < 0.005) was discerned; no 
      correlation was observed between antibodies to the blood stage or the 
      circumsporozoite protein of P. vivax and the circumsporozoite protein of P. 
      falciparum. In addition, P. falciparum-infected erythrocyte lysate specifically 
      abrogated binding of Gag-specific antibodies in HTLV-Iind specimens from regions 
      where malaria is endemic without affecting binding in HTLV-I-seropositive 
      specimens, suggesting that the immunologic cross-reactivity between HTLV Gag 
      proteins and malaria parasites is restricted to the blood-stage antigens of 
      plasmodia in specimens from regions where malaria is endemic. However, 
      HTLV-seroindeterminate specimens from the United States did not demonstrate 
      serologic cross-reactivity, suggesting that antigenic mimicry of HTLV proteins 
      extends to other nonplasmodial antigens as well.
FAU - Lal, R B
AU  - Lal RB
AD  - Retrovirus Diseases Branch, Centers for Disease Control and Prevention, Atlanta, 
      Georgia 30333, USA.
FAU - Rudolph, D
AU  - Rudolph D
FAU - Alpers, M P
AU  - Alpers MP
FAU - Sulzer, A J
AU  - Sulzer AJ
FAU - Shi, Y P
AU  - Shi YP
FAU - Lal, A A
AU  - Lal AA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Antigens, Protozoan)
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Animals
MH  - Antigens, Protozoan/blood/*immunology
MH  - Binding Sites, Antibody
MH  - Binding, Competitive/immunology
MH  - Cross Reactions
MH  - Erythrocytes/immunology
MH  - HTLV-I Antibodies/blood
MH  - Humans
MH  - Malaria, Falciparum/*blood/immunology/parasitology
MH  - Plasmodium falciparum/growth & development/*immunology
MH  - Viral Structural Proteins/blood/*immunology
PMC - PMC368187
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
PMCR- 1994/01/01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PHST- 1994/01/01 00:00 [pmc-release]
AID - 10.1128/cdli.1.1.5-10.1994 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 1994 Jan;1(1):5-10. doi: 10.1128/cdli.1.1.5-10.1994.