PMID- 7496961
OWN - NLM
STAT- MEDLINE
DCOM- 19960116
LR  - 20221207
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 1
IP  - 3
DP  - 1994 May
TI  - Elevated levels of total and Puumala virus-specific immunoglobulin E in the 
      Scandinavian type of hemorrhagic fever with renal syndrome.
PG  - 269-72
AB  - In a previous study, it was reported that the total immunoglobulin E (IgE) level 
      was increased in patients with hemorrhagic fever with renal syndrome (HFRS). The 
      aim of the present study was to investigate whether specific IgE is synthesized 
      during the course of the disease. For this purpose, an epsilon-capture 
      enzyme-linked immunosorbent assay was developed. A total of 72 patients with HFRS 
      caused by Puumala virus were studied. Three different control groups were 
      included: 20 blood donors, 20 patients with other viral diseases (influenza A and 
      B virus, acute Epstein-Barr virus, and acute cytomegalovirus infections), and 5 
      subjects with high levels of total IgE (median, 1,070 kU/liter; range, 773 to 
      5,740 kU/liter). The levels of total IgE were significantly higher during the 
      acute phase of HFRS than those of blood donors (P < 0.01) and of patients with 
      other viral diseases (P < 0.001). All patients developed a specific IgE response 
      (median, 55 arbitrary units; range 24 to 123 arbitrary units) in the acute phase 
      of the disease, whereas in the different control groups no specific IgE was 
      detectable. Both total and specific IgE levels decreased during convalescence 
      compared with those during the acute phase of HFRS (P < 0.001 and P < 0.001, 
      respectively). In conclusion, we have shown that both total and specific IgE 
      levels are increased in patients with HFRS compared with levels in patients with 
      other viral diseases. The possible pathogenetic role of the specific IgE response 
      in HFRS is discussed.
FAU - Alexeyev, O A
AU  - Alexeyev OA
AD  - Department of Virology, University Hospital of Northern Sweden, Umea, Sweden.
FAU - Ahlm, C
AU  - Ahlm C
FAU - Billheden, J
AU  - Billheden J
FAU - Settergren, B
AU  - Settergren B
FAU - Wadell, G
AU  - Wadell G
FAU - Juto, P
AU  - Juto P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Antibodies, Viral)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*biosynthesis/blood
MH  - *Antibody Specificity
MH  - Female
MH  - Orthohantavirus/*immunology
MH  - Hemorrhagic Fever with Renal Syndrome/classification/*immunology
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis/blood
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC368247
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
PMCR- 1994/05/01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
PHST- 1994/05/01 00:00 [pmc-release]
AID - 10.1128/cdli.1.3.269-272.1994 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 1994 May;1(3):269-72. doi: 10.1128/cdli.1.3.269-272.1994.