PMID- 7498720
OWN - NLM
STAT- MEDLINE
DCOM- 19960118
LR  - 20061115
IS  - 0016-5751 (Print)
IS  - 0016-5751 (Linking)
VI  - 55
IP  - 9
DP  - 1995 Sep
TI  - [Cytogenetic abnormalities in sperm: a risk factor for application of medical 
      reproduction techniques?].
PG  - 518-25
AB  - Microinsemination techniques are increasingly applied to achieve fertilisation of 
      the oocyte in cases of male fertility disorders. Thus, spermatozoa can directly 
      interact with the oolemma or the ooplasm, thereby obviating the need for 
      penetration through cumulus oophorus and zona pellucida. However, problems 
      associated with this particular feature arise in view of the following 
      considerations: 1. The gametes from subfertile males are suspected to carry more 
      cytogenetic anomalies in addition to an impaired sperm quality when compared to 
      fertile men. 2. Cumulus and zona play an important role in the selection of 
      morphologically abnormal and dysfunctional spermatozoa. 3. Consequently, 
      bypassing natural sperm selection processes would lead to more abnormal embryos, 
      abortions, and births of diseased or handicapped children. Spermatozoa can be 
      analysed cytogenetically after fusion with zona-free hamster eggs or by 
      fluorescence in situ hybridization (FISH). Both techniques did not confirm 
      increased aberrations in gametes from subfertile men with a normal somatic 
      karyotype. However, a definite conclusion cannot be drawn because of the limited 
      data and restrictions concerning their interpretation. This also holds true for 
      the evaluation of correlations indicating no significant relationship between the 
      chromosomal constitution and sperm motility or morphology, respectively. 
      Currently, the risk of malformation after microinsemination does not appear to be 
      increased when compared to conventional IVF but the results do not yet allow a 
      reliable statistical evaluation. In contrast, decreased morphological quality, 
      impaired implantation, and early abortions have been reported for embryos 
      produced by assisted fertilisation. This suggests that an effective natural 
      selection of abnormal embryos will prevent a significant increase in 
      malformations in the following generation.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Rosenbusch, B
AU  - Rosenbusch B
AD  - Abt. Frauenheilkunde und Geburtshilfe der Universitat Ulm.
FAU - Strehler, E
AU  - Strehler E
FAU - Sterzik, K
AU  - Sterzik K
FAU - Kreienberg, R
AU  - Kreienberg R
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Zytogenetische Anomalien in Spermien: Ein Risikofaktor bei Anwendung 
      reproduktionsmedizinischer Techniken?
PL  - Germany
TA  - Geburtshilfe Frauenheilkd
JT  - Geburtshilfe und Frauenheilkunde
JID - 0370732
SB  - IM
MH  - *Chromosome Aberrations
MH  - Female
MH  - Fertilization in Vitro/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Microinjections
MH  - *Reproductive Techniques
MH  - Risk Factors
MH  - Sperm-Ovum Interactions
MH  - Spermatozoa/*abnormalities
RF  - 40
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1055/s-2007-1022831 [doi]
PST - ppublish
SO  - Geburtshilfe Frauenheilkd. 1995 Sep;55(9):518-25. doi: 10.1055/s-2007-1022831.