PMID- 7499865
OWN - NLM
STAT- MEDLINE
DCOM- 19960118
LR  - 20210102
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 155
IP  - 12
DP  - 1995 Dec 15
TI  - Controlled recruitment of monocytes and macrophages to specific organs through 
      transgenic expression of monocyte chemoattractant protein-1.
PG  - 5769-76
AB  - Transgenic mice overexpressing the chemokine monocyte chemoattractant protein-1 
      (MCP-1) in the thymus and central nervous system have a higher number of 
      mononuclear cells in those tissues than do control littermates. In the thymus, 
      there is a modest increase in the number of Mac-1 and F4/80 positive cells, but 
      no apparent change in the number of lymphoid cells. A more pronounced mononuclear 
      infiltrate is detected in transgenic mice expressing MCP-1 in the brain. The vast 
      majority of the recruited cells in the brain are monocytes and macrophages, as 
      defined by light microscopy, and ultrastructural and immunohistochemical 
      criteria. Such cells are found in a perivascular orientation with minimal 
      parenchymal infiltration, possibly as a consequence of the accumulation of MCP-1 
      in the vessels, as shown by immunohistochemistry. The mononuclear cell infiltrate 
      in the brain can be significantly amplified by LPS treatment, suggesting that the 
      recruitment properties of MCP-1 can be potentiated by additional factors.
FAU - Fuentes, M E
AU  - Fuentes ME
AD  - Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research 
      Institute, Princeton, NJ 08543, USA.
FAU - Durham, S K
AU  - Durham SK
FAU - Swerdel, M R
AU  - Swerdel MR
FAU - Lewin, A C
AU  - Lewin AC
FAU - Barton, D S
AU  - Barton DS
FAU - Megill, J R
AU  - Megill JR
FAU - Bravo, R
AU  - Bravo R
FAU - Lira, S A
AU  - Lira SA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Blood Vessels/ultrastructure
MH  - Brain/drug effects/ultrastructure
MH  - Chemokine CCL2/*physiology
MH  - Chemotactic Factors/*physiology
MH  - Chemotaxis, Leukocyte/*physiology
MH  - Lipopolysaccharides
MH  - Macrophages/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Monocytes/*physiology
MH  - Thymus Gland/drug effects/ultrastructure
EDAT- 1995/12/15 00:00
MHDA- 1995/12/15 00:01
CRDT- 1995/12/15 00:00
PHST- 1995/12/15 00:00 [pubmed]
PHST- 1995/12/15 00:01 [medline]
PHST- 1995/12/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1995 Dec 15;155(12):5769-76.