PMID- 7504521
OWN - NLM
STAT- MEDLINE
DCOM- 19940113
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 8
IP  - 2
DP  - 1993 Oct
TI  - Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 
      expression in B-cell malignancies.
PG  - 80-7
AB  - We have analyzed the BCL1 locus in a series of 24 B-cell tumors and cell lines 
      with rearrangements of 11q13 (mostly t(11;14)(q13;q32) translocations). Using 
      Southern hybridization and/or fluorescence in situ hybridization (FISH) on 
      metaphase chromosomes, we have not only confirmed the scattering of the 
      breakpoints between the BCL1 locus and the cyclin D1 gene (CCND1), but also shown 
      that some of the breakpoints could be as far as 500 kb on either side of the 
      latter. Expression of CCND1 was not restricted to cases with t(11;14)(q13;q32), 
      but was also associated with other 11q13 rearrangements, such as a 
      t(8;11)(p22;q13). Whatever the alteration at 11q13, a correlation was observed 
      between the expression of CCND1 and the presence of a breakpoint within 150 kb 
      upstream of the gene. On the contrary, three samples, including a bona fide 
      t(11;14) translocation and two cases with breakpoints located outside the 
      BCL1-CCND1 area, did not exhibit detectable levels of CCND1 transcripts. Our 
      results raise the possibility that several discrete molecular events can take 
      place at 11q13 in B-cell malignancies.
FAU - Raynaud, S D
AU  - Raynaud SD
AD  - LGMCH, CNRS URA1462, Nice, France.
FAU - Bekri, S
AU  - Bekri S
FAU - Leroux, D
AU  - Leroux D
FAU - Grosgeorge, J
AU  - Grosgeorge J
FAU - Klein, B
AU  - Klein B
FAU - Bastard, C
AU  - Bastard C
FAU - Gaudray, P
AU  - Gaudray P
FAU - Simon, M P
AU  - Simon MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Cyclins)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Oncogene Proteins)
RN  - 0 (RNA, Neoplasm)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
GS  - BCL1
GS  - CCND1
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 11
MH  - Cosmids
MH  - Cyclin D1
MH  - Cyclins/*biosynthesis
MH  - DNA, Neoplasm/analysis/chemistry
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Rearrangement, B-Lymphocyte
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, B-Cell/*genetics
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Molecular Sequence Data
MH  - Multiple Myeloma/*genetics
MH  - Oncogene Proteins/*biosynthesis
MH  - Polymorphism, Restriction Fragment Length
MH  - Prospective Studies
MH  - RNA, Neoplasm/analysis/biosynthesis
MH  - Restriction Mapping
MH  - Retrospective Studies
MH  - Transcription, Genetic
MH  - *Translocation, Genetic
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1002/gcc.2870080204 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1993 Oct;8(2):80-7. doi: 10.1002/gcc.2870080204.