PMID- 7505413
OWN - NLM
STAT- MEDLINE
DCOM- 19940125
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 159
IP  - 1-2
DP  - 1993 Sep 3
TI  - Central administration of senktide, a tachykinin NK-3 agonist, has an 
      antidiuretic action by stimulating AVP release in water-loaded rats.
PG  - 187-90
AB  - Intracerebroventricular (i.c.v.) injections of senktide (0.01-10 nmol), a 
      tachykinin NK-3 agonist, had an antidiuretic action in water-loaded rats (4.5% 
      body wt.). Pretreatment with OPC-31260 (1 mg/kg, i.v.), a non-peptide vasopressin 
      V2 antagonist, inhibited the antidiuretic action induced by exogenous arginine 
      vasopressin (AVP, 0.1 micrograms/kg, i.v.) and senktide (0.1 nmol, i.c.v.). In 
      addition, senktide (11.8 nmol, i.c.v.) caused a marked increase of the plasma AVP 
      level in conscious rats. These results suggest that the central NKB analogue 
      senktide has an antidiuretic effect by stimulating AVP secretion from the 
      pituitary gland through the NK-3 receptor in the hypothalamus.
FAU - Saigo, A
AU  - Saigo A
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka 
      University, Japan.
FAU - Takano, Y
AU  - Takano Y
FAU - Matsumoto, T
AU  - Matsumoto T
FAU - Tran, M
AU  - Tran M
FAU - Nakayama, Y
AU  - Nakayama Y
FAU - Saito, R
AU  - Saito R
FAU - Yamada, K
AU  - Yamada K
FAU - Kamiya, H
AU  - Kamiya H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Benzazepines)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Neurokinin-3)
RN  - 059QF0KO0R (Water)
RN  - 106128-89-6 (senktide)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 17OJ42922Y (mozavaptan)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/antagonists & inhibitors/blood/*metabolism
MH  - Benzazepines/pharmacology
MH  - Diuresis/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptide Fragments/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Neurokinin-3/*physiology
MH  - Substance P/administration & dosage/*analogs & derivatives/antagonists & 
      inhibitors/pharmacology
MH  - Urodynamics/drug effects
MH  - Water/pharmacology
EDAT- 1993/09/03 00:00
MHDA- 1993/09/03 00:01
CRDT- 1993/09/03 00:00
PHST- 1993/09/03 00:00 [pubmed]
PHST- 1993/09/03 00:01 [medline]
PHST- 1993/09/03 00:00 [entrez]
AID - 0304-3940(93)90830-E [pii]
AID - 10.1016/0304-3940(93)90830-e [doi]
PST - ppublish
SO  - Neurosci Lett. 1993 Sep 3;159(1-2):187-90. doi: 10.1016/0304-3940(93)90830-e.