PMID- 7505952
OWN - NLM
STAT- MEDLINE
DCOM- 19940202
LR  - 20211203
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 263
IP  - 5143
DP  - 1994 Jan 7
TI  - The Met proto-oncogene mesenchymal to epithelial cell conversion.
PG  - 98-101
AB  - Coexpression of the human Met receptor and its ligand, hepatocyte growth 
      factor/scatter factor (HGF/SF), in NIH 3T3 fibroblasts causes the cells to become 
      tumorigenic in nude mice. The resultant tumors display lumen-like morphology, 
      contain carcinoma-like focal areas with intercellular junctions resembling 
      desmosomes, and coexpress epithelial (cytokeratin) and mesenchymal (vimentin) 
      cytoskeletal markers. The tumor cells also display enhanced expression of 
      desmosomal and tight-junction proteins. The apparent mesenchymal to epithelial 
      conversion of the tumor cells mimics the conversion that occurs during embryonic 
      kidney development, suggesting that Met-HGF/SF signaling plays a role in this 
      process as well as in tumors that express both epithelial and mesenchymal 
      markers.
FAU - Tsarfaty, I
AU  - Tsarfaty I
AD  - ABL-Basic Research Program, National Cancer Institute (NCI)-Frederick Cancer 
      Research and Development Center, MD 21702-1201.
FAU - Rong, S
AU  - Rong S
FAU - Resau, J H
AU  - Resau JH
FAU - Rulong, S
AU  - Rulong S
FAU - da Silva, P P
AU  - da Silva PP
FAU - Vande Woude, G F
AU  - Vande Woude GF
LA  - eng
GR  - N01-CO-74101/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Vimentin)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 68238-35-7 (Keratins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
GS  - Met
MH  - 3T3 Cells
MH  - Animals
MH  - *Cell Transformation, Neoplastic
MH  - Desmosomes/ultrastructure
MH  - Epithelial Cells
MH  - Hepatocyte Growth Factor/metabolism/pharmacology
MH  - Keratins/biosynthesis
MH  - Kidney/embryology/metabolism
MH  - Mesoderm/cytology
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasms, Experimental/metabolism/*pathology
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-met
MH  - *Proto-Oncogenes
MH  - Receptor Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Signal Transduction
MH  - Transfection
MH  - Vimentin/biosynthesis
EDAT- 1994/01/07 00:00
MHDA- 1994/01/07 00:01
CRDT- 1994/01/07 00:00
PHST- 1994/01/07 00:00 [pubmed]
PHST- 1994/01/07 00:01 [medline]
PHST- 1994/01/07 00:00 [entrez]
AID - 10.1126/science.7505952 [doi]
PST - ppublish
SO  - Science. 1994 Jan 7;263(5143):98-101. doi: 10.1126/science.7505952.