PMID- 7506387
OWN - NLM
STAT- MEDLINE
DCOM- 19940208
LR  - 20231213
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 320
IP  - 1-2
DP  - 1994 Jan
TI  - Mutagenic effects of nitropyrenes in a soybean test system.
PG  - 59-68
AB  - The mutagenic activity of 1-nitropyrene (1-NP), 1,3-dinitropyrene (1,3-DNP), 
      1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP) was assayed in 
      heterozygous soybean plants (Y11y11), based on the appearance of mutational spots 
      (yellow, dark green and twin) on the leaves. 1-NP, 1,3-DNP, 1,6-DNP and 1,8-DNP 
      were direct-acting mutagens in a soybean test system, and mutagenicity was 
      enhanced by addition of pyrene as a precursor. The mutagenicity of dinitropyrenes 
      was enhanced by pretreatment with hepatic microsomal fractions of Aroclor 
      1254-treated rats. Binary and ternary isomeric mixtures of dinitropyrenes 
      produced synergistic mutational response in the test system. The numbers of 
      yellow and dark green spots per leaf increased by treatment with nitropyrenes. 
      The frequency of twin spots did not change. Nitropyrenes stimulated the induction 
      of forward and reverse mutations in soybeans. The number of light green spots 
      (Y11y11) per leaf on homozygous soybeans (y11y11) increased markedly by treatment 
      with 1-NP, 1,3-DNP, 1,6-DNP, and 1,8-DNP. These nitropyrenes would thus appear to 
      cause point mutation and segmental loss as major effects.
FAU - Katoh, Y
AU  - Katoh Y
AD  - Life Science Division, Hokkaido Institute of Public Health, Japan.
FAU - Maekawa, M
AU  - Maekawa M
FAU - Sano, Y
AU  - Sano Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Liver Extracts)
RN  - 0 (Mutagens)
RN  - 0 (Pyrenes)
RN  - 51U7E9MW6I (1,8-dinitropyrene)
RN  - 66Q2ZUF83N (1,6-dinitropyrene)
RN  - D09D9L0924 (1,3-dinitropyrene)
RN  - TD1665I8Q4 (1-nitropyrene)
SB  - IM
MH  - Chi-Square Distribution
MH  - Chromatography, High Pressure Liquid
MH  - *Chromosome Deletion
MH  - Drug Synergism
MH  - Isomerism
MH  - Liver Extracts
MH  - Microsomes, Liver/enzymology
MH  - Mutagenicity Tests
MH  - Mutagens/*toxicity
MH  - *Point Mutation
MH  - Pyrenes/*toxicity
MH  - Glycine max/*drug effects/genetics
MH  - Structure-Activity Relationship
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0165-1218(94)90059-0 [pii]
AID - 10.1016/0165-1218(94)90059-0 [doi]
PST - ppublish
SO  - Mutat Res. 1994 Jan;320(1-2):59-68. doi: 10.1016/0165-1218(94)90059-0.