PMID- 7507449
OWN - NLM
STAT- MEDLINE
DCOM- 19940225
LR  - 20220321
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 161
IP  - 1
DP  - 1994 Jan
TI  - Tumor necrosis factor-alpha (TNF-alpha) stimulates proliferation of mouse 
      primordial germ cells in culture.
PG  - 91-5
AB  - Recent studies have shown that stem cell factor, leukemia inhibitory factor, and 
      basic fibroblast growth factor increase proliferation and survival of the mouse 
      primordial germ cells (PGCs) in culture. We now show that addition of tumor 
      necrosis factor-alpha (TNF-alpha) to culture medium stimulates proliferation of 
      PGCs without transforming them into embryonic stem cells and that its effect is 
      specific for the PGCs at younger stages before and during their migration to 
      gonads. A previously reported finding that TNF-alpha is expressed at these stages 
      in mouse embryos suggests possible involvement of TNF-alpha in the proliferative 
      regulation of the PGCs in the embryo.
FAU - Kawase, E
AU  - Kawase E
AD  - Mammalian Development Laboratory, National Institute of Genetics, Mishima, Japan.
FAU - Yamamoto, H
AU  - Yamamoto H
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Nakatsuji, N
AU  - Nakatsuji N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Growth Inhibitors)
RN  - 0 (Hematopoietic Cell Growth Factors)
RN  - 0 (Interleukin-6)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Lif protein, mouse)
RN  - 0 (Lymphokines)
RN  - 0 (Stem Cell Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Embryo, Mammalian/*cytology
MH  - Female
MH  - Germ Cells/*cytology/drug effects
MH  - Growth Inhibitors/pharmacology
MH  - Hematopoietic Cell Growth Factors/pharmacology
MH  - *Interleukin-6
MH  - Leukemia Inhibitory Factor
MH  - Lymphokines/pharmacology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pregnancy
MH  - Stem Cell Factor
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - S0012-1606(84)71011-6 [pii]
AID - 10.1006/dbio.1994.1011 [doi]
PST - ppublish
SO  - Dev Biol. 1994 Jan;161(1):91-5. doi: 10.1006/dbio.1994.1011.