PMID- 7507564
OWN - NLM
STAT- MEDLINE
DCOM- 19940302
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 316
IP  - 1
DP  - 1994 Feb
TI  - The frequency of micronuclei with X chromosome increases with age in human 
      females.
PG  - 1-7
AB  - The rate of micronuclei counted on lymphocyte cultures from five healthy female 
      donors, 27-80 years old, increased with age. Using pXBR1 probe, specific for the 
      alphoid DNA of the X chromosome, the presence of this chromosome was investigated 
      by FISH (fluorescence in situ hybridization) in both micronuclei and metaphases. 
      Both X aneuploidy and frequency of X chromosome per micronuclei increased with 
      age. However, this overinvolvement of X chromosome was not sufficient to explain 
      the overall increase of micronuclei with age, suggesting that autosomes are also 
      involved. Thus, the higher increase of X than autosome aneuploidy in lymphocytes 
      may result from both an excess of X chromosome losses and a better survival of 
      cells with a monosomy X.
FAU - Richard, F
AU  - Richard F
AD  - URA 620 CNRS, Institut Curie, Section de Biologie, Paris, France.
FAU - Muleris, M
AU  - Muleris M
FAU - Dutrillaux, B
AU  - Dutrillaux B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (DNA Probes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*genetics
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Linear Models
MH  - Lymphocytes/ultrastructure
MH  - Micronuclei, Chromosome-Defective/*pathology
MH  - Middle Aged
MH  - Monosomy
MH  - Probability
MH  - X Chromosome/*pathology
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1016/0921-8734(94)90002-7 [doi]
PST - ppublish
SO  - Mutat Res. 1994 Feb;316(1):1-7. doi: 10.1016/0921-8734(94)90002-7.