PMID- 7507681
OWN - NLM
STAT- MEDLINE
DCOM- 19940310
LR  - 20180215
IS  - 1015-2008 (Print)
IS  - 1015-2008 (Linking)
VI  - 61
IP  - 5-6
DP  - 1993
TI  - In situ expression of cytokines and cellular adhesion molecules in the skin of 
      patients with systemic sclerosis. Their role in early and late disease.
PG  - 239-46
AB  - Cytokines and cellular adhesion molecules (CAMs) may play a role in the 
      inflammatory and fibrotic processes underlying systemic sclerosis (SSc). We 
      compared the immunohistological distribution of cytokines and CAMs in skin 
      biopsies from 12 SSc patients and 14 normal (NL) individuals. Among CAMs, 
      vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte-endothelial 
      adhesion, showed increased expression on SSc versus NL endothelium and stratum 
      granulosum. P-selectin was up-regulated in SSc versus NL stratum granulosum. The 
      CD44 lymphocyte homing receptor showed the most striking differences between SSc 
      and NL: its expression was increased in SSc stratum granulosum, stratum spinosum, 
      on lymphocytes, and macrophages. Regarding cytokines, interleukin-6 (IL-6) 
      expression was increased on SSc versus NL endothelium and fibroblasts. Tumor 
      necrosis factor-alpha (TNF-alpha) reactivity was more prevalent in SSc than NL 
      stratum granulosum, whereas IL-8 expression was higher on SSc compared to NL 
      endothelium. Some CAMs, such as VCAM-1 and P-selectin, and cytokines, namely 
      TNF-alpha and IL-8, were more commonly found in skin biopsies taken from early (< 
      or = 1 year's duration) SSc, while others, such as IL-6, showed up-regulation in 
      the late stage of the disease. The results suggest that certain CAMs and 
      cytokines may play a differential role in both the early, inflammatory, and the 
      late, fibrotic stage of SSc.
FAU - Koch, A E
AU  - Koch AE
AD  - Department of Medicine, Northwestern University Medical School, Chicago, IL 
      60611.
FAU - Kronfeld-Harrington, L B
AU  - Kronfeld-Harrington LB
FAU - Szekanecz, Z
AU  - Szekanecz Z
FAU - Cho, M M
AU  - Cho MM
FAU - Haines, G K
AU  - Haines GK
FAU - Harlow, L A
AU  - Harlow LA
FAU - Strieter, R M
AU  - Strieter RM
FAU - Kunkel, S L
AU  - Kunkel SL
FAU - Massa, M C
AU  - Massa MC
FAU - Barr, W G
AU  - Barr WG
AU  - et al.
LA  - eng
GR  - AR-30692/AR/NIAMS NIH HHS/United States
GR  - AR-41492/AR/NIAMS NIH HHS/United States
GR  - HL-02401/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (P-Selectin)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Lymphocyte Homing)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Carrier Proteins/analysis/metabolism/physiology
MH  - Cell Adhesion/physiology
MH  - Cell Adhesion Molecules/*analysis/metabolism/*physiology
MH  - Cytokines/*analysis/metabolism/*physiology
MH  - Endothelium/metabolism/pathology/physiology
MH  - Female
MH  - Fibroblasts/metabolism/pathology/physiology
MH  - Humans
MH  - Hyaluronan Receptors
MH  - Immunohistochemistry
MH  - Interleukin-6/analysis/metabolism/physiology
MH  - Interleukin-8/analysis/metabolism/physiology
MH  - Male
MH  - Middle Aged
MH  - P-Selectin
MH  - Platelet Membrane Glycoproteins/analysis/metabolism/physiology
MH  - Receptors, Cell Surface/analysis/metabolism/physiology
MH  - Receptors, Lymphocyte Homing/analysis/metabolism/physiology
MH  - Scleroderma, Systemic/*metabolism/pathology/*physiopathology
MH  - Skin/*chemistry/pathology/*physiopathology
MH  - Tumor Necrosis Factor-alpha/analysis/metabolism/physiology
MH  - Vascular Cell Adhesion Molecule-1
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1159/000163802 [doi]
PST - ppublish
SO  - Pathobiology. 1993;61(5-6):239-46. doi: 10.1159/000163802.