PMID- 7507696
OWN - NLM
STAT- MEDLINE
DCOM- 19940310
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 9
IP  - 1
DP  - 1994 Jan
TI  - Trisomy 7: a potential cytogenetic marker of human prostate cancer progression.
PG  - 19-27
AB  - We used the fluorescence in situ hybridization (FISH) method to show that 
      chromosome 7 trisomy is associated with the progression of human prostate cancer. 
      Thirty-six specimens including 15 primary prostate carcinomas, 16 metastatic 
      lesions, and 5 normal prostate tissues, as well as 2 prostate carcinoma cell 
      lines of different tumorigenic potential, were examined for chromosome 7 
      aneuploidy. Our results showed that the androgen-unresponsive tumorigenic cell 
      line PC-3 exhibited a significantly higher ratio of chromosome 7 to total 
      chromosome number than the androgen-responsive nontumorigenic cell line LNCaP (P 
      = 0.001). In prostate specimens, the frequency of trisomy 7 cells was 
      significantly increased (P < 0.05) in the advanced stage tumors (C and DI) but 
      not in the early (B) stage tumors or normal prostatic tissue. Furthermore, 
      metastases showed a higher frequency of trisomy 7 cells than primary tumors (P = 
      0.005). In 2 patients with paired primary and metastatic tumors, trisomy 7 cells 
      increased from 4-7% in the primary tumors to 42-45% in the metastatic tumor cells 
      in the bone marrow. Therefore, our data suggest that trisomy 7 may be a common 
      feature associated with local and metastatic progression and serve as a novel 
      marker for human prostate cancer progression.
FAU - Bandyk, M G
AU  - Bandyk MG
AD  - Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston 
      77030.
FAU - Zhao, L
AU  - Zhao L
FAU - Troncoso, P
AU  - Troncoso P
FAU - Pisters, L L
AU  - Pisters LL
FAU - Palmer, J L
AU  - Palmer JL
FAU - von Eschenbach, A C
AU  - von Eschenbach AC
FAU - Chung, L W
AU  - Chung LW
FAU - Liang, J C
AU  - Liang JC
LA  - eng
GR  - CA-56307/CA/NCI NIH HHS/United States
GR  - R01-CA43585/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Genetic Markers)
SB  - IM
MH  - *Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 9
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Prostatic Neoplasms/*genetics/pathology
MH  - *Trisomy
MH  - Tumor Cells, Cultured
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1002/gcc.2870090105 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1994 Jan;9(1):19-27. doi: 10.1002/gcc.2870090105.