PMID- 7508058
OWN - NLM
STAT- MEDLINE
DCOM- 19940308
LR  - 20131121
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 22 Suppl 6
DP  - 1993
TI  - Comparative effects of indapamide and hydrochlorothiazide on cardiac hypertrophy 
      and vascular smooth-muscle phenotype in the stroke-prone, spontaneously 
      hypertensive rat.
PG  - S29-34
AB  - The effects of two diuretics, indapamide (3 mg/kg/day) and hydrochlorothiazide 
      (20 mg/kg/day), were analyzed over a 44-day period on the cardiovascular 
      hypertrophy of stroke-prone spontaneously hypertensive rats (SHR-SP). Untreated 
      SHR-SP developed severe hypertension and cardiac hypertrophy when compared to 
      normotensive Wistar-Kyoto (WKY) rats after 8 weeks on 1% sodium chloride. In 
      diuretic-treated animals, systolic blood pressure was moderately decreased by the 
      end of the treatment when compared with untreated SHR-SP (-13 and -18%, 
      respectively, p < or = 0.05). Morphometric analysis of myocyte cross-sectional 
      areas evidenced that indapamide was the most effective in preventing myocyte 
      hypertrophy (-33%, p < or = 0.0001). Small coronary artery wall thickness was 
      efficiently prevented in the two treated groups, but medial hypertrophy was 
      prevented by hydrochlorothiazide only. Among markers of smooth-muscle cell 
      phenotype (contractile or extracellular matrix proteins) EIIIA-fibronectin (FN), 
      one FN cellular isoform, was shown to be the most sensitive marker by an 
      immunohistochemical technic. Medial expression of EIIIA-FN, which was 
      characteristic of SHR-SP coronary arteries, was prevented by the two treatments. 
      The two diuretic treatments, despite similar effects on blood pressure and 
      smooth-muscle phenotype, prevent SHR-SP cardiovascular hypertrophy with a 
      drug-specific efficiency.
FAU - Contard, F
AU  - Contard F
AD  - Unite 127 INSERM, Hopital Lariboisiere, Paris, France.
FAU - Glukhova, M
AU  - Glukhova M
FAU - Sabri, A
AU  - Sabri A
FAU - Marotte, F
AU  - Marotte F
FAU - Sartore, S
AU  - Sartore S
FAU - Narcisse, G
AU  - Narcisse G
FAU - Schatz, C
AU  - Schatz C
FAU - Guez, D
AU  - Guez D
FAU - Rappaport, L
AU  - Rappaport L
FAU - Samuel, J L
AU  - Samuel JL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0J48LPH2TH (Hydrochlorothiazide)
RN  - F089I0511L (Indapamide)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cardiomegaly/etiology/*prevention & control
MH  - Coronary Vessels/*drug effects/pathology
MH  - Hydrochlorothiazide/pharmacology/*therapeutic use
MH  - Hypertension/complications/*drug therapy
MH  - Indapamide/pharmacology/*therapeutic use
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth, Vascular/*drug effects/pathology/physiopathology
MH  - Myocardium/pathology
MH  - Phenotype
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1993;22 Suppl 6:S29-34.