PMID- 7508737
OWN - NLM
STAT- MEDLINE
DCOM- 19940318
LR  - 20161021
IS  - 1121-7596 (Print)
IS  - 1121-7596 (Linking)
VI  - 5
IP  - 1
DP  - 1993 Apr
TI  - Thyroid autoantibodies in the subsets of lupus erythematosus: correlation with 
      other autoantibodies and thyroid function.
PG  - 1-7
AB  - Thirty four sera from: 12 patients with Systemic Lupus Erythematosus (SLE), 9 
      with Subacute Cutaneous Lupus Erythematosus (SCLE) and 13 with Discoid Lupus 
      Erythematosus (DLE) (disseminatus 3, localised 10) were tested for the presence 
      of: (a) anti-thyroglobulin and anti-microsomal autoantibodies (b) anti-Sm/RNP, 
      anti-doublestranded. DNA (anti-ds. DNA), anti-single-Stranded. DNA (anti-ss. 
      DNA), anti-cardiolipin (anti-Cl), anti-SSA, anti-SSB, Antinuclear Antibodies 
      (ANA). T3, T4, TSH levels were also determined. Five patients with SLE (41.6%), 4 
      with SCLE (44.4%), and 2 with DLE (15.3%) had thyroid autoantibodies and only 
      three of the 41 controls (7.3%). Five patients (14.7%), especially from SLE and 
      SCLE groups, had biochemical hypothyroidism whereas only one had hyperthyroidism. 
      Statistical evaluation for the possible coexistence of thyroid autoantibodies 
      with a panel of lupus characteristic autoantibodies, revealed highly significant 
      correlations with anti-Sm/RNP, IgG (p = 0.003) and anti-ds. DNA, IgM (p = 0.012). 
      It may be concluded, that not only SLE but also SCLE predisposes to autoimmune 
      thyroid disease and the prevalence of the latter is related to a great extent to 
      the subset of the LE spectrum. From these results and from the inhibition 
      experiments, it seems that some of the specific mono- or polyclonal 
      autoantibodies may be multiple organ reactive.
FAU - Konstadoulakis, M M
AU  - Konstadoulakis MM
AD  - Hippokration Hospital, Dept. of Surgery, Univ. of Athens, Greece.
FAU - Kroubouzos, G
AU  - Kroubouzos G
FAU - Tosca, A
AU  - Tosca A
FAU - Piperingos, G
AU  - Piperingos G
FAU - Marafelia, P
AU  - Marafelia P
FAU - Konstadoulakis, M
AU  - Konstadoulakis M
FAU - Varelzidis, A
AU  - Varelzidis A
FAU - Koutras, D A
AU  - Koutras DA
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Thyroidology
JT  - Thyroidology
JID - 9100266
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Ribonucleoproteins, Small Nuclear)
RN  - 0 (anti-thyroglobulin)
RN  - 0 (snRNP Core Proteins)
RN  - 0 (thyroid microsomal antibodies)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/blood
MH  - Autoantibodies/*blood
MH  - Autoantigens/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/blood
MH  - Lupus Erythematosus, Cutaneous/*immunology/physiopathology
MH  - Lupus Erythematosus, Discoid/*immunology/physiopathology
MH  - Lupus Erythematosus, Systemic/*immunology/physiopathology
MH  - Male
MH  - *Ribonucleoproteins, Small Nuclear
MH  - Thyroid Gland/*immunology/*physiopathology
MH  - snRNP Core Proteins
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
PST - ppublish
SO  - Thyroidology. 1993 Apr;5(1):1-7.