PMID- 7509749
OWN - NLM
STAT- MEDLINE
DCOM- 19940404
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 250
IP  - 1
DP  - 1993 Nov 30
TI  - Metabotropic and ionotropic excitatory amino acid receptor agonists induce 
      different behavioral effects in mice.
PG  - 15-22
AB  - Intracerebroventricular (i.c.v.) infusion in mice of the selective metabotropic 
      excitatory amino acid receptor agonist 1S,3R-1- 
      aminocyclopentane-1,3-dicarboxylate (1S,3R-ACPD) (0.6-575 nmol/min) dose 
      dependently induced face washing and scratching. In contrast, the 
      subtype-specific ionotropic excitatory amino acid receptor agonists 
      N-methyl-D-aspartate (NMDA), kainate and 
      alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) (0.3-3.0 nmol/min) 
      dose dependently induced clonic convulsions. I.c.v. infusion of the non-selective 
      metabotropic receptor agonists ibotenate (6 nmol/min) or quisqualate (30 
      nmol/min) induced clonic convulsions. However, when ionotropic receptors were 
      blocked with (+)-5-methyl-10,11-dihydro-5H-dibenzo-(a,d)cyclohepten-5,10-imine 
      maleate (MK-801, dizoclipine) (3 nmol/min) or 2,3-dihydroxy-6-nitro-7- 
      sulfamoyl-benzo(f)-quinoxaline (NBQX) (9 nmol/min), respectively, face washing 
      and scratching behavior emerged. Neither MK-801 or NBQX (ED50 value > 100 
      nmol/min), nor the putative metabotropic receptor antagonist 
      L-amino-3-phosphoro-propionic acid (L-AP3) (> 176 nmol/min); nor the dopamine 
      receptor antagonists SCH 23390 (> 74 nmol/min), metoclopramide (> 89 nmol/min) 
      and haloperidol (> 27 nmol/min) antagonized 1S,3R-ACPD-induced scratching (144 
      nmol/min). These results suggest that the behavioral consequences of i.c.v. 
      infusion of 1S,3R-ACPD in mice reflect a selective activation of metabotropic 
      receptors that differs from the behavioral changes observed with i.c.v. infusion 
      of ionotropic receptor agonists.
FAU - Laudrup, P
AU  - Laudrup P
AD  - Department of Neurophysiology, Novo Nordisk A/S, Malov, Denmark.
FAU - Klitgaard, H
AU  - Klitgaard H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, Glutamate)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cycloleucine/administration & dosage/*analogs & 
      derivatives/pharmacology/therapeutic use
MH  - Dizocilpine Maleate/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Ibotenic Acid/pharmacology
MH  - Kainic Acid/administration & dosage/*pharmacology/therapeutic use
MH  - Male
MH  - Mice
MH  - N-Methylaspartate/administration & dosage/*pharmacology/therapeutic use
MH  - Quinoxalines/pharmacology
MH  - Quisqualic Acid/pharmacology
MH  - Receptors, Glutamate/*drug effects/metabolism
MH  - Seizures/chemically induced/drug therapy
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/administration & 
      dosage/*pharmacology/therapeutic use
EDAT- 1993/11/30 00:00
MHDA- 1993/11/30 00:01
CRDT- 1993/11/30 00:00
PHST- 1993/11/30 00:00 [pubmed]
PHST- 1993/11/30 00:01 [medline]
PHST- 1993/11/30 00:00 [entrez]
AID - 0014-2999(93)90615-O [pii]
AID - 10.1016/0014-2999(93)90615-o [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1993 Nov 30;250(1):15-22. doi: 10.1016/0014-2999(93)90615-o.