PMID- 7509842
OWN - NLM
STAT- MEDLINE
DCOM- 19940405
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 55
IP  - 3
DP  - 1994 Mar
TI  - Beta 2-adrenoceptor agonists regulate the IL-4-induced phenotypical changes and 
      IgE-dependent functions in normal human monocytes.
PG  - 313-20
AB  - The beta 2-adrenoceptor agonists salbutamol and fenoterol were tested for their 
      regulatory effects on human monocyte phenotype and functions, either alone or in 
      combination with interleukin-4 (IL-4). These drugs enhanced in a dose-dependent 
      manner the IL-4-induced membrane and mRNA expression of the low-affinity receptor 
      for immunoglobulin E (IgE) (CD23), as well as the release of its soluble form, 
      sCD23. Salbutamol and fenoterol alone elicited expression of the monomorphic beta 
      2-chain (CD18) of the leukocyte functional antigen (LFA1) family. This effect 
      appeared to be restricted to CD11b (CR3) and CD11c (gp 150-95), because CD11a 
      (LFA-1 alpha chain) was not modified. beta 2-Adrenoceptor stimulation was also 
      found to potentiate the effect of IL-4 on CD11b, CD11c, and CD18 expression. In 
      contrast, these agents alone did not alter the level of major histocompatibility 
      complex class II and CD14 antigens or modify their respective up- and 
      down-regulation by IL-4. Ligation of CD23 on IL-4-preincubated (CD23+) monocytes 
      with IgE/anti-IgE immune complexes induced the release of free radicals nitric 
      oxide and of the proinflammatory mediators IL-6 and thromboxane B2 (TxB2). 
      Addition of salbutamol, inactive alone, potentiated the generation of superoxide 
      anion and of nitric oxide generation, as well as the production of IL-6 and TxB2 
      triggered by CD23 ligation. These results indicate that beta 2-adrenoceptor 
      stimulation potentiates in vitro the IL-4-induced phenotypical and functional 
      changes on monocytes and suggest that such an interaction could occur in 
      IgE-dependent immune reactions.
FAU - Paul-Eugene, N
AU  - Paul-Eugene N
AD  - INSERM U 365, Institut Curie, Paris, France.
FAU - Kolb, J P
AU  - Kolb JP
FAU - Damais, C
AU  - Damais C
FAU - Abadie, A
AU  - Abadie A
FAU - Mencia-Huerta, J M
AU  - Mencia-Huerta JM
FAU - Braquet, P
AU  - Braquet P
FAU - Bousquet, J
AU  - Bousquet J
FAU - Dugas, B
AU  - Dugas B
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Lymphocyte Function-Associated Antigen-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 0 (Receptors, IgE)
RN  - 11062-77-4 (Superoxides)
RN  - 207137-56-2 (Interleukin-4)
RN  - 22M9P70OQ9 (Fenoterol)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 54397-85-2 (Thromboxane B2)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Albuterol/pharmacology
MH  - Antigens, CD/analysis/genetics/metabolism
MH  - Antigens, Differentiation, Myelomonocytic/analysis/genetics/metabolism
MH  - Blotting, Northern
MH  - Cells, Cultured
MH  - Fenoterol/pharmacology
MH  - Fluorescent Antibody Technique
MH  - Histocompatibility Antigens Class II/analysis/genetics/metabolism
MH  - Humans
MH  - Immunoglobulin E/*pharmacology
MH  - Interleukin-4/*pharmacology
MH  - Interleukin-6/metabolism
MH  - Lipopolysaccharide Receptors
MH  - Lymphocyte Function-Associated Antigen-1/genetics/metabolism/physiology
MH  - Monocytes/chemistry/*cytology/*physiology
MH  - Phenotype
MH  - RNA, Messenger/analysis/genetics
MH  - Receptors, Adrenergic, beta/*physiology
MH  - Receptors, IgE/genetics/metabolism/physiology
MH  - Superoxides/metabolism
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Thromboxane B2/metabolism
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1002/jlb.55.3.313 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1994 Mar;55(3):313-20. doi: 10.1002/jlb.55.3.313.