PMID- 7509889
OWN - NLM
STAT- MEDLINE
DCOM- 19940405
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 63
IP  - 4
DP  - 1993 Dec
TI  - Protective effect of N-acyl amino acids (NAAs) on cephaloridine (CER) 
      nephrotoxicity in rabbits.
PG  - 487-93
AB  - The protective effect of N-acyl amino acids (NAAs) against cephaloridine 
      (CER)-induced nephrotoxicity was studied in rabbits. A large single intravenous 
      dose of CER (more than 100 mg/kg) induced severe proximal tubular necrosis. 
      Simultaneous treatment with several NAAs (at dosages of 100, 200 mg/kg, etc., 
      i.v.), such as N-benzoyl-beta-alanine (NBBA), N-benzoyl-6-aminocaproic acid, and 
      N alpha,epsilon-dibenzoyl-D,L-lysine, remarkably suppressed the histopathological 
      damage in the kidney induced by CER. NAAs have generally low toxicity in 
      laboratory animals (e.g., the LD50 of NBBA was more than 3,000 mg/kg, i.v. in 
      rats), and NAAs were suggested to be good candidates for reducing the 
      nephrotoxicity of CER and other beta-lactam antibiotics.
FAU - Hirouchi, Y
AU  - Hirouchi Y
AD  - Product Development Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
FAU - Naganuma, H
AU  - Naganuma H
FAU - Kawahara, Y
AU  - Kawahara Y
FAU - Okada, R
AU  - Okada R
FAU - Kamiya, A
AU  - Kamiya A
FAU - Inui, K
AU  - Inui K
FAU - Hori, R
AU  - Hori R
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Amino Acids)
RN  - 2198-64-3 (N-benzoylalanine)
RN  - LVZ1VC61HB (Cephaloridine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Alanine/*analogs & derivatives/pharmacology
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Cephaloridine/administration & dosage/*toxicity
MH  - Histocytochemistry
MH  - Injections, Intravenous
MH  - Kidney Tubules, Proximal/*drug effects/pathology
MH  - Male
MH  - Necrosis/chemically induced
MH  - Rabbits
MH  - Staining and Labeling
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1254/jjp.63.487 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1993 Dec;63(4):487-93. doi: 10.1254/jjp.63.487.