PMID- 7512368
OWN - NLM
STAT- MEDLINE
DCOM- 19940513
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 8
IP  - 4
DP  - 1993 Dec
TI  - Analysis of deletions of the long arm of chromosome 11 in hematologic 
      malignancies with fluorescence in situ hybridization.
PG  - 246-52
AB  - We studied samples containing deletions of the long arm of chromosome 11 (11q) 
      from patients with hematologic malignancies by using cytogenetic and fluorescence 
      in situ hybridization (FISH) techniques. Cytogenetic analysis of 28 patients and 
      of a cell line showed that all deletions included band 11q23. FISH analysis 
      demonstrated that the proximal part of 11q23, including NCAM, was deleted in 13 
      of 15 patients and the cell line. Recurring chromosomal losses in human tumors 
      have been regarded as evidence that the affected regions contain tumor-suppressor 
      genes. These results suggest that the putative tumor-suppressor gene is proximal 
      to the MLL gene which is also located in 11q23.
FAU - Kobayashi, H
AU  - Kobayashi H
AD  - Department of Medicine, University of Chicago, IL 60637.
FAU - Espinosa, R 3rd
AU  - Espinosa R 3rd
FAU - Fernald, A A
AU  - Fernald AA
FAU - Begy, C
AU  - Begy C
FAU - Diaz, M O
AU  - Diaz MO
FAU - Le Beau, M M
AU  - Le Beau MM
FAU - Rowley, J D
AU  - Rowley JD
LA  - eng
GR  - CA 40046/CA/NCI NIH HHS/United States
GR  - CA38725/CA/NCI NIH HHS/United States
GR  - CA42577/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
GS  - ETS1
GS  - INS
GS  - MLL
GS  - NCAM
GS  - PLZF
GS  - RB1
GS  - RCKD1
GS  - TP53
MH  - Adolescent
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/*ultrastructure
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia/genetics
MH  - Lymphoma, Non-Hodgkin/genetics
MH  - Lymphoproliferative Disorders/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Oncogenes
EDAT- 1993/12/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1002/gcc.2870080407 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1993 Dec;8(4):246-52. doi: 10.1002/gcc.2870080407.