PMID- 7515659
OWN - NLM
STAT- MEDLINE
DCOM- 19940712
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 9
IP  - 3
DP  - 1994 Mar
TI  - Detailed analysis of loss of heterozygosity on chromosome band 17p13 in breast 
      carcinoma on the basis of a high-resolution physical map with 29 markers.
PG  - 173-9
AB  - We have constructed a physical map of chromosome band 17p13, using 29 markers 
      that had been localized to 17p13 by means of fluorescence in situ hybridization 
      (FISH) and analysis by pulsed-field gel electrophoresis (PFGE). The map spans 
      nearly 8 Mb of genomic DNA, and the estimated average distance between each 
      marker is roughly 290 kb. The p13 band of chromosome 17 is thought to contain a 
      putative tumor suppressor gene in addition and distal to TP53. Deletion mapping 
      in a large number of breast carcinomas indicated that the tumor suppressor gene 
      lies between the loci defined by cC117-708 (D17S878) and p144D6 (D17S34), which 
      are an estimated 7 Mb apart. Our results should contribute to construction of a 
      contig map of chromosome band 17p13 with cosmid and/or YAC (yeast artificial 
      chromosome) clones, and to isolation of the putative tumor suppressor gene.
FAU - Isomura, M
AU  - Isomura M
AD  - Department of Biochemistry, Cancer Institute, Tokyo, Japan.
FAU - Tanigami, A
AU  - Tanigami A
FAU - Saito, H
AU  - Saito H
FAU - Harada, Y
AU  - Harada Y
FAU - Katagiri, T
AU  - Katagiri T
FAU - Inazawa, J
AU  - Inazawa J
FAU - Ledbetter, D H
AU  - Ledbetter DH
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 17/ultrastructure
MH  - DNA, Neoplasm/analysis
MH  - Genes, Tumor Suppressor
MH  - Genetic Markers
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - *Sequence Deletion
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1002/gcc.2870090305 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1994 Mar;9(3):173-9. doi: 10.1002/gcc.2870090305.