PMID- 7516042
OWN - NLM
STAT- MEDLINE
DCOM- 19940712
LR  - 20190516
IS  - 0470-8105 (Print)
IS  - 0470-8105 (Linking)
VI  - 34
IP  - 3
DP  - 1994 Mar
TI  - Immunophenotypic analysis of primary malignant lymphoma of the brain.
PG  - 136-42
AB  - The immunophenotypes in three cases of primary malignant lymphomas of the brain 
      were analyzed by flow cytometry using a panel of monoclonal antibodies. In all 
      three cases the immunophenotypes were CD10 negative, CD19 positive, and CD20 
      positive, and in two cases human leukocyte antigen (HLA)-DR positive. CD20 showed 
      high positivity (80-97%), while CD19 revealed low positivity (30-50%). These 
      neoplastic cells apparently became malignant at the B-cell differentiation stage, 
      when they expressed both CD19 and CD20. Differentiation continued until CD19 was 
      no longer expressed, when further differentiation stopped between the last stage 
      of B-cell differentiation and the early stage of plasma cell formation (Case 3 
      was CD38 positive). Case 1 was immunoblastic type lymphoma and the cells were 
      both surface immunoglobulin and HLA-DR negative. At least 40% of Case 2 cells 
      showed both B-cell and T-cell markers. Immunophenotypic study can help determine 
      the cell lineage, clonality, and stage of differentiation of lymphoid neoplasms.
FAU - Arai, T
AU  - Arai T
AD  - Division of Neurosurgery, Tochigi Cancer Center, Utsunomiya.
FAU - Nagai, M
AU  - Nagai M
FAU - Okuhata, S
AU  - Okuhata S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Neurol Med Chir (Tokyo)
JT  - Neurologia medico-chirurgica
JID - 0400775
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Monoclonal/immunology
MH  - Antigens, CD/immunology
MH  - Brain Neoplasms/diagnosis/*immunology/ultrastructure
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/immunology
MH  - Humans
MH  - *Immunophenotyping
MH  - Lymphoma, Non-Hodgkin/diagnosis/*immunology/ultrastructure
MH  - Male
MH  - Photomicrography
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - JST.Journalarchive/nmc1959/34.136 [pii]
AID - 10.2176/nmc.34.136 [doi]
PST - ppublish
SO  - Neurol Med Chir (Tokyo). 1994 Mar;34(3):136-42. doi: 10.2176/nmc.34.136.