PMID- 7516637
OWN - NLM
STAT- MEDLINE
DCOM- 19940718
LR  - 20131121
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 14
IP  - 2B
DP  - 1994 Mar-Apr
TI  - Cisplatin, 5-fluorouracil and alpha interferon in non small cell lung carcinoma: 
      a toxicity study.
PG  - 621-5
AB  - Data are presented on the general and hematological toxicity of a cisplatin 
      (DDP), 5-fluorouracil (5-FU) and alpha interferon (IFN-alpha) association in 
      patients with stage III B or IV non small cell lung cancer (NSCLC). Twenty 
      patients received DDP (100 mg/mq i.v., day 1) and 5-FU (750 mg/mq/day i.v. 
      continuous infusion, days 1 to 4). In ten of these patients IFN-alpha (3 MU s.c., 
      three times weekly, days 1 to 21) was added. General and hematological toxicity 
      was of a similar degree in both groups. Recombinant granulocyte colony 
      stimulating factor (G-CSF; 5 micrograms/kg b.w. s.c. days 7 to 18) induced a 
      sharp increase in peripheral blood GM-CFU level in patients receiving DDP and 
      5-FU but not in DDP, 5-FU, IFN-alpha treated patients. The results appear to 
      indicate that IFN-alpha modulation of a DDP, 5-FU combination induces an 
      acceptable degree of toxicity.
FAU - Castello, G
AU  - Castello G
AD  - Department of Internal Medicine, University of Genoa, Italy.
FAU - Lerza, R
AU  - Lerza R
FAU - Mencoboni, M
AU  - Mencoboni M
FAU - Cavallini, D
AU  - Cavallini D
FAU - Flego, G
AU  - Flego G
FAU - Cerruti, A
AU  - Cerruti A
FAU - Ballarino, P
AU  - Ballarino P
FAU - Bogliolo, G
AU  - Bogliolo G
FAU - Pannacciulli, I
AU  - Pannacciulli I
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - Q20Q21Q62J (Cisplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/drug therapy/pathology/*therapy
MH  - Cisplatin/therapeutic use/*toxicity
MH  - Colony-Forming Units Assay
MH  - Female
MH  - Fluorouracil/therapeutic use/*toxicity
MH  - Granulocyte Colony-Stimulating Factor/*therapeutic use
MH  - Humans
MH  - Interferon-alpha/therapeutic use/*toxicity
MH  - Leukocyte Count/drug effects
MH  - Lung Neoplasms/drug therapy/pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Recombinant Proteins/therapeutic use
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1994 Mar-Apr;14(2B):621-5.