PMID- 7516728
OWN - NLM
STAT- MEDLINE
DCOM- 19940728
LR  - 20191031
IS  - 0778-3124 (Print)
IS  - 0778-3124 (Linking)
VI  - 102
IP  - 1
DP  - 1994 Jan-Feb
TI  - Exercise-induced increase of plasma lactate is abolished by a pre-exercise 
      epinephrine infusion.
PG  - 21-6
AB  - The purpose of this study was to determine the effect of a higher than normal 
      epinephrine content in skeletal muscles, on metabolic and hormonal adjustments 
      during a subsequent exercise. Four groups of 10 rats were studied: two control 
      groups, one at rest and one after an exercise leading to exhaustion on a 
      treadmill (28 m.min-1, 8% grade) and two epinephrine-infused groups (EI), one at 
      rest and one after the same type of exercise. Epinephrine-infused rats (EI) 
      received an infusion of epinephrine (5 nM.kg.min-1, i.v.) for 20 minutes, and 
      were rested 20 minutes before the start of the exercise or rest period. In the 
      soleus muscle, epinephrine content was shown to be multiplied by 15 and 8 times 
      the control values, respectively following 20 and 60 min after the end of the 
      infusion. Control rats received a corresponding volume of sterile saline with the 
      same schedule. The exercise lasted 49 +/- 14 vs 54 +/- 6 minutes respectively for 
      EI and control rats (not significant). At rest, plasma concentrations of 
      epinephrine, norepinephrine, plasma free fatty acids, glycerol, glucose and 
      lactate as well as the glycogen content of the liver, the soleus, gastrocnemius 
      lateralis and superficial vastus lateralis muscles were not different between 
      saline and epinephrine-infused rats. Immediately after exercise, plasma lactate 
      concentration was not increased after exercise in EI vs (2.26 +/- 0.39 vs 4.53 
      +/- 0.73 mM). One possible explanation of this observation is that re-released 
      epinephrine might induce a vasodilation in the splanchnic or the skeletal muscle 
      vascular beds and thus favors lactate clearance during exercise.
FAU - Trudeau, F
AU  - Trudeau F
AD  - Departement des sciences de l'activite physique, Universite du Quebec a 
      Trois-Rivieres.
FAU - Brisson, G
AU  - Brisson G
FAU - Beauregard, F
AU  - Beauregard F
FAU - Peronnet, F
AU  - Peronnet F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Belgium
TA  - Arch Int Physiol Biochim Biophys
JT  - Archives internationales de physiologie, de biochimie et de biophysique
JID - 9111069
RN  - 0 (Blood Glucose)
RN  - 0 (Lactates)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9005-79-2 (Glycogen)
RN  - 9007-92-5 (Glucagon)
RN  - PDC6A3C0OX (Glycerol)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Epinephrine/administration & dosage/metabolism/*pharmacology
MH  - Glucagon/blood
MH  - Glycerol/blood
MH  - Glycogen/metabolism
MH  - Kinetics
MH  - Lactates/*blood
MH  - Lactic Acid
MH  - Liver/metabolism
MH  - Male
MH  - Muscles/metabolism
MH  - Norepinephrine/metabolism
MH  - Physical Exertion/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.3109/13813459408996101 [doi]
PST - ppublish
SO  - Arch Int Physiol Biochim Biophys. 1994 Jan-Feb;102(1):21-6. doi: 
      10.3109/13813459408996101.