PMID- 7517321
OWN - NLM
STAT- MEDLINE
DCOM- 19940804
LR  - 20131121
IS  - 1081-0803 (Print)
IS  - 1081-0803 (Linking)
VI  - 10
IP  - 2 Suppl
DP  - 1994 Mar-Apr
TI  - Use of topical nonsteroidal anti-inflammatory drugs after photorefractive 
      keratectomy.
PG  - S287-9
AB  - BACKGROUND: Photorefractive keratectomy (PRK) requires a careful pharmacologic 
      regimen during the postoperative period to reduce corneal haze and refractive 
      myopic regression. Noncorticosteroidal anti-inflammatory drugs limit postablative 
      corneal inflammation without the complications that may occur during 
      corticosteroid treatment. METHODS: Twenty consecutive eyes of 10 patients with 
      attempted correction ranging from 4.00 to 9.00 D of myopia were studied. During 
      the postoperative period, corticosteroid drops (dexamethasone 0.1%) were 
      instilled in the first eye of each patient, and the second eye was treated with 
      diclofenac sodium ophthalmic solution 0.1% (Voltaren). Follow-up was 12 months 
      after surgery. RESULTS: Corneal haze and refraction were studied. Six of the 10 
      eyes treated with noncorticosteroidal anti-inflammatory drugs did not show any 
      significant difference in corneal haze and refractive evolution compared to the 
      contralateral eyes treated with corticosteroids. Two eyes (20%) showed less 
      corneal haze and more refractive stability than the contralateral eyes. In two 
      eyes (20%), we observed similar corneal haze but more refractive regression than 
      in the contralateral eyes. CONCLUSIONS: Eyes treated with topical diclofenac 
      sodium had a similar postoperative course as those treated with corticosteroids, 
      but without the adverse effects of corticosteroids. Topical nonsteroidal 
      anti-inflammatory drugs are represented by diclofenac (Voltaren), which has 
      significant ocular penetration. This permits reduction of the possibility of 
      general and ocular complications that frequently occur with corticosteroids. The 
      aim of this study was to evaluate the efficacy of topical nonsteroidal 
      antiinflammatory drugs vs. corticosteroidal eyedrops after photorefractive 
      keratectomy (PRK) to reduce moderate and high myopia.
FAU - Ferrari, M
AU  - Ferrari M
AD  - Resnati S. Raffaele Hospital Eye Clinic, Milan, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Refract Corneal Surg
JT  - Journal of refractive and corneal surgery
JID - 9431306
RN  - 0 (Ophthalmic Solutions)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Administration, Topical
MH  - Cornea/*surgery
MH  - Dexamethasone/*administration & dosage/adverse effects
MH  - Diclofenac/*administration & dosage
MH  - Follow-Up Studies
MH  - Humans
MH  - *Laser Therapy/adverse effects
MH  - Myopia/*surgery
MH  - Ophthalmic Solutions
MH  - Postoperative Complications/prevention & control
MH  - Refraction, Ocular
MH  - Visual Acuity
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
PST - ppublish
SO  - J Refract Corneal Surg. 1994 Mar-Apr;10(2 Suppl):S287-9.