PMID- 7517462
OWN - NLM
STAT- MEDLINE
DCOM- 19940729
LR  - 20190825
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 35
IP  - 2
DP  - 1994 Mar
TI  - Days required for 75% suppression of ventricular premature contractions by 
      antiarrhythmic agents obtained from continuous in-hospital ECG monitoring.
PG  - 125-40
AB  - To determine the number of days required to obtain 75% suppression of ventricular 
      premature contractions (VPCs) by antiarrhythmic agents, which was expressed as 
      t1/4, we performed 32 in-hospital continuous all day ECG monitoring trials in 
      four groups of 28 symptomatic patients (ages; 54 +/- 20 years-old) with frequent 
      VPCs. Nine patients had no organic heart disease (group 1, 11 trials), nine had 
      valvular heart disease (group 2, 10 trials), three had dilated cardiomyopathy 
      (group 3, 3 trials) and seven had myocardial infarction within two to four weeks 
      onset (group 4, 8 trials). All patients were monitored by ECG telemetry with an 
      arrhythmia analyzer, which could count hourly and daily VPCs. Class I 
      antiarrhythmic agents were given in 18 trials, class II in two trials and class 
      I+ class II in 12 trials. Plasma concentrations of the antiarrhythmic agents were 
      monitored in 11 trials. In 21 trials, t1/4 could be obtained; ten (91%), six 
      (60%), three (100%) and two trials (25%) in the four groups, respectively (p < 
      0.05). The value of t1/4 in the four groups was 6 +/- 6, 7 +/- 6, 14 +/- 11 and 
      13 +/- 2 days, respectively (mean 8 +/- 7 days; N.S.). Immediate response to the 
      initial antiarrhythmic agent administration, expressed as percent VPC count after 
      three hours, correlated significantly with t1/4 (r = 0.696, p = 0.0006), but 
      ejection fraction, patient's age, control VPC counts or plasma antiarrhythmic 
      agent level did not correlate with t1/4. In conclusion, t1/4 is a useful index 
      for the evaluation of VPC suppression, revealing wide inter-individual variations 
      and can be roughly estimated from the immediate response to the initial 
      antiarrhythmic agent administration.
FAU - Fujito, T
AU  - Fujito T
AD  - Department of Cardiology, Koshigaya Hospital, Dokkyo University School of 
      Medicine, Saitama, Japan.
FAU - Takayanagi, K
AU  - Takayanagi K
FAU - Shimizu, M
AU  - Shimizu M
FAU - Inoue, T
AU  - Inoue T
FAU - Hayashi, T
AU  - Hayashi T
FAU - Sakai, Y
AU  - Sakai Y
FAU - Morooka, S
AU  - Morooka S
FAU - Takabatake, Y
AU  - Takabatake Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
RN  - 0 (Anti-Arrhythmia Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Arrhythmia Agents/pharmacokinetics/*therapeutic use
MH  - Cardiac Complexes, Premature/diagnosis/*drug therapy
MH  - Cardiomyopathy, Dilated/complications
MH  - *Electrocardiography, Ambulatory/instrumentation
MH  - Female
MH  - Heart Valve Diseases/complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications
MH  - Stroke Volume
MH  - Time Factors
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1536/ihj.35.125 [doi]
PST - ppublish
SO  - Jpn Heart J. 1994 Mar;35(2):125-40. doi: 10.1536/ihj.35.125.